Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Dapagliflozin
Drug ID BADD_D00578
Description Dapagliflozin is a sodium-glucose cotransporter 2 inhibitor indicated for managing diabetes mellitus type 2.[A6757] When combined with diet and exercise in adults, dapagliflozin helps to improve glycemic control by inhibiting glucose resorption in the proximal tubule of the nephron and causing glycosuria.[A6757] Dapagliflozin was approved by the FDA on Jan 08, 2014.[L6034]
Indications and Usage Dapagliflozin is indicated for adjunct management of glycemic control in patients with type 2 diabetes mellitus, in combination with diet and exercise.
Marketing Status Prescription
ATC Code A10BK01
DrugBank ID DB06292
KEGG ID D08897
MeSH ID C529054
PubChem ID 9887712
TTD Drug ID D01TNW
NDC Product Code 17228-6205; 50090-3482; 14501-0028; 55154-6932; 59285-012; 66529-0003; 54921-621; 55111-987; 69037-0027; 65727-073; 12783-1428; 50090-3481; 0310-6205; 17228-6210; 12783-1427; 54921-620; 55154-6933; 46708-897; 66064-1029; 50193-1427; 59651-135; 0310-6210; 66039-933
Synonyms dapagliflozin | (2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6- (hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol | Farxiga | Forxiga | 2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol | BMS 512148 | BMS512148 | BMS-512148
Chemical Information
Molecular Formula C21H25ClO6
CAS Registry Number 461432-26-8
SMILES CCOC1=CC=C(C=C1)CC2=C(C=CC(=C2)C3C(C(C(C(O3)CO)O)O)O)Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Blood urea increased13.13.01.006--Not Available
Burning sensation17.02.06.001; 08.01.09.029--Not Available
Carcinogenicity12.03.01.038--Not Available
Cardiovascular disorder24.03.02.009; 02.01.01.0010.000629%Not Available
Cellulitis11.02.01.001; 23.09.01.0010.001809%Not Available
Cerebrovascular accident24.03.05.001; 17.08.01.007--
Chest discomfort02.02.02.009; 22.02.08.001; 08.01.08.019--Not Available
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.0110.006632%Not Available
Chills15.05.03.016; 08.01.09.001--
Chromaturia20.02.01.0020.002412%
Confusional state19.13.01.001; 17.02.03.005--
Constipation07.02.02.001--
Cough22.02.03.001--
Creatinine renal clearance increased13.13.01.0150.001206%Not Available
Cystitis20.03.02.002; 11.01.14.0010.001809%
Death08.04.01.001--
Dehydration14.05.05.0010.013867%
Depression19.15.01.001--
Dermatitis23.03.04.002--Not Available
Diabetes mellitus14.06.01.001; 05.06.01.001--Not Available
Diabetes mellitus inadequate control14.06.01.004; 05.06.01.0040.006029%Not Available
Diabetic hyperosmolar coma17.02.09.003; 14.07.04.001; 05.07.04.0010.001206%Not Available
Diabetic ketoacidosis05.07.03.001; 14.07.03.0010.148318%Not Available
Diarrhoea07.02.01.001--
Discomfort08.01.08.003--Not Available
Dizziness17.02.05.003; 24.06.02.007; 02.01.02.0040.022308%
Drug hypersensitivity10.01.01.001--Not Available
Dry mouth07.06.01.002--
Dry skin23.03.03.001--
Dysarthria19.19.03.001; 17.02.08.001--
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