Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Dantrolene sodium
Drug ID BADD_D00577
Description Chemically, dantrolene is a hydantoin derivative, but does not exhibit antiepileptic activity like other hydantoin derivates such as phenytoin.
Indications and Usage For use, along with appropriate supportive measures, for the management of the fulminant hypermetabolism of skeletal muscle characteristic of malignant hyperthermia crises in patients of all ages. Also used preoperatively, and sometimes postoperatively, to prevent or attenuate the development of clinical and laboratory signs of malignant hyperthermia in individuals judged to be malignant hyperthermia susceptible.
Marketing Status Prescription
ATC Code M03CA01
DrugBank ID DB01219
KEGG ID D02274
MeSH ID D003620
PubChem ID 6604100
TTD Drug ID D0I8DD
NDC Product Code 69988-0029; 42023-124; 69575-4036; 42023-123; 0527-3220; 42367-540; 71052-508; 0527-3219; 0115-4433; 67262-2000; 68084-300; 55718-105; 49452-2440; 55154-7140; 50268-217; 27505-003; 78670-003; 0115-4422; 65129-1012; 0115-4411; 63629-2170; 49884-363; 49884-362; 63629-2168; 49884-364; 0527-3221; 63629-2169
Synonyms Dantrolene | Dantrolene Sodium | Sodium, Dantrolene | Dantrium
Chemical Information
Molecular Formula C14H9N4NaO5
CAS Registry Number 7261-97-4
SMILES C1C(=NC(=O)N1N=CC2=CC=C(O2)C3=CC=C(C=C3)[N+](=O)[O-])[O-].[Na+]
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Acne23.02.01.001--Not Available
Anaemia01.03.02.001--
Anaphylactic reaction24.06.03.006; 10.01.07.001--
Anaphylactic shock24.06.02.004; 10.01.07.002--Not Available
Aplastic anaemia01.03.03.002--Not Available
Asthenia08.01.01.001--Not Available
Atrioventricular block02.03.01.002--Not Available
Back pain15.03.04.005--
Blood pressure fluctuation24.06.01.002--Not Available
Body temperature increased13.15.01.001--Not Available
Cardiac failure02.05.01.001--
Chills08.01.09.001; 15.05.03.016--
Choking sensation22.02.05.002; 19.01.02.002--Not Available
Chromaturia20.02.01.002--
Coagulopathy01.01.02.001--Not Available
Confusional state19.13.01.001; 17.02.03.005--
Constipation07.02.02.001--
Crystalluria20.02.01.003--Not Available
Depression19.15.01.001--
Dermatitis23.03.04.002--Not Available
Dermatitis acneiform23.02.01.004--
Diarrhoea07.02.01.001--
Diplopia17.17.01.005; 06.02.06.002--Not Available
Discomfort08.01.08.003--Not Available
Dizziness17.02.05.003; 02.01.02.004; 24.06.02.007--
Drooling17.02.05.005--Not Available
Dry mouth07.06.01.002--
Dysgeusia17.02.07.003; 07.14.03.001--
Dyspepsia07.01.02.001--
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