Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Dalfampridine
Drug ID BADD_D00574
Description Dalfampridine is a potassium channel blocker used to help multiple sclerosis patients walk. This is the first drug that was specifically approved to help with mobility in these patients. FDA approved on January 22, 2010.
Indications and Usage Dalfampridine is a neurofunctional modifier that helps improve walking speed in patients with multiple sclerosis (MS).
Marketing Status Prescription
ATC Code N07XX07
DrugBank ID DB06637
KEGG ID D04127
MeSH ID D015761
PubChem ID 1727
TTD Drug ID D08YIN
NDC Product Code 38779-3205; 42571-338; 63190-0510; 46016-5042; 16729-292; 56125-427; 62756-429; 0054-0479; 42571-275; 51927-5030; 12817-054; 54382-125; 62756-038; 63190-0530; 51407-246; 65862-917; 65372-1157; 65862-863; 62991-3143; 67877-444; 10144-427; 0378-0509
Synonyms 4-Aminopyridine | 4 Aminopyridine | Dalfampridine | Pymadine | VMI-103 | VMI 103 | VMI103 | 4-Aminopyridine Sustained Release | 4 Aminopyridine Sustained Release | Sustained Release, 4-Aminopyridine | Fampridine-SR | Fampridine SR
Chemical Information
Molecular Formula C5H6N2
CAS Registry Number 504-24-5
SMILES C1=CN=CC=C1N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Lymphopenia01.02.02.002--Not Available
Malaise08.01.01.0030.094116%
Malignant melanoma23.08.01.001; 16.03.01.001--Not Available
Mass08.03.05.0030.005229%Not Available
Mean cell volume abnormal13.01.05.0140.005229%Not Available
Mean cell volume increased13.01.05.0220.002614%Not Available
Memory impairment19.20.01.003; 17.03.02.0030.053594%
Mental impairment19.21.02.003; 17.03.03.002--Not Available
Micturition urgency20.02.02.0060.019607%
Middle insomnia19.02.01.003; 17.15.03.0030.006536%Not Available
Migraine24.03.05.003; 17.14.02.0010.014379%Not Available
Monocyte count increased13.01.06.0090.006536%Not Available
Mood altered19.04.02.007--Not Available
Movement disorder17.01.02.0100.026143%Not Available
Multiple sclerosis17.16.01.001; 10.04.10.0080.098037%Not Available
Muscle spasms15.05.03.0040.054901%
Muscle spasticity15.05.04.011; 17.05.03.0070.014379%
Muscle twitching15.05.03.0050.006536%Not Available
Muscular weakness17.05.03.005; 15.05.06.0010.117645%
Musculoskeletal pain15.03.04.0070.014379%
Myalgia15.05.02.001--
Myasthenia gravis17.05.04.001; 15.05.08.001; 10.04.05.0010.002614%
Myelopathy17.10.01.0070.002614%Not Available
Myocardial infarction02.02.02.007; 24.04.04.009--
Nasal congestion22.04.04.001--
Nasopharyngitis22.07.03.002; 11.01.13.0020.026143%Not Available
Nausea07.01.07.001--
Neck pain15.03.04.0090.018300%
Neoplasm malignant16.16.01.001--Not Available
Neoplasm skin23.08.02.003; 16.03.02.0030.002614%Not Available
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