| Pharmaceutical Information |
| Drug Name |
Dacarbazine |
| Drug ID |
BADD_D00568 |
| Description |
An antineoplastic agent. It has significant activity against melanomas. (from Martindale, The Extra Pharmacopoeia, 31st ed, p564). Dacarbazine with Oblimersen is in clinical trials for the treatment of malignant melanoma. |
| Indications and Usage |
For the treatment of metastatic malignant melanoma. In addition, dacarbazine is also indicated for Hodgkin's disease as a secondary-line therapy when used in combination with other antineoplastic agents. |
| Marketing Status |
Prescription; Discontinued |
| ATC Code |
L01AX04 |
| DrugBank ID |
DB00851
|
| KEGG ID |
D00288
|
| MeSH ID |
D003606
|
| PubChem ID |
2942
|
| TTD Drug ID |
D0Y7ZU
|
| NDC Product Code |
54875-0003; 0143-9245; 42973-149; 0703-5075; 63323-128; 63323-127 |
| Synonyms |
Dacarbazine | Dimethyl Imidazole Carboxamide | Carboxamide, Dimethyl Imidazole | Imidazole Carboxamide, Dimethyl | DTIC | ICDT | Decarbazine | 5-(3,3-Dimethyl-1-triazeno)imidazole-4-carboxamide | DIC | Dimethyl Triazeno Imidazole Carboxamide | NSC-45388 | NSC 45388 | NSC45388 | DTIC-Dome | DTIC Dome | DTICDome | Biocarbazine | Deticene |
|
| Chemical Information |
| Molecular Formula |
C6H10N6O |
| CAS Registry Number |
4342-03-4 |
| SMILES |
CN(C)N=NC1=C(NC=N1)C(=O)N |
| Chemical Structure |
|
|
| ADR Related Proteins Induced by Drug |
| ADR Term |
Protein Name |
UniProt AC |
TTD Target ID |
PMID |
| Not Available | Not Available | Not Available | Not Available | Not Available |
|
| ADRs Induced by Drug |
|
| ADR Term |
ADReCS ID |
ADR Frequency (FAERS)
|
ADR Severity Grade (FAERS)
|
ADR Severity Grade (CTCAE)
|
| Platelet toxicity | 12.03.01.057; 01.08.03.004 | 0.000347% | | Not Available |
|
|
|
