Pharmaceutical Information |
Drug Name |
Dabrafenib |
Drug ID |
BADD_D00566 |
Description |
Dabrafenib mesylate (Tafinlar) is a reversible ATP-competitive kinase inhibitor and targets the MAPK pathway. It was approved on May 29, 2013 for the treatment of melanoma [L2718].
In May 2018, Tafinlar (dabrafenib) and Mekinist ([DB08911]) in combination have been approved to treat anaplastic thyroid cancer caused by an abnormal BRAF V600E gene [L2714]. |
Indications and Usage |
Dabrafenib is indicated for the treatment of patients with unresectable or metastatic melanoma with BRAF V600E mutation as detected by an FDA-approved test. |
Marketing Status |
Not Available |
ATC Code |
L01EC02 |
DrugBank ID |
DB08912
|
KEGG ID |
D10064
|
MeSH ID |
C561627
|
PubChem ID |
44462760
|
TTD Drug ID |
D05ROI
|
NDC Product Code |
0078-0682; 0078-0681; 52482-007 |
Synonyms |
dabrafenib | GSK 2118436 | GSK2118436 | GSK-2118436 |
|
Chemical Information |
Molecular Formula |
C23H20F3N5O2S2 |
CAS Registry Number |
1195765-45-7 |
SMILES |
CC(C)(C)C1=NC(=C(S1)C2=NC(=NC=C2)N)C3=C(C(=CC=C3)NS(=O)(=O)C4=C(C=CC=C4F)F)F |
Chemical Structure |
|
|
ADR Related Proteins Induced by Drug |
ADR Term |
Protein Name |
UniProt AC |
TTD Target ID |
PMID |
Not Available | Not Available | Not Available | Not Available | Not Available |
|
ADRs Induced by Drug |
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