Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Cytarabine
Drug ID BADD_D00560
Description A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant properties. (From Martindale, The Extra Pharmacopoeia, 30th ed, p472)
Indications and Usage For the treatment of acute non-lymphocytic leukemia, acute lymphocytic leukemia and blast phase of chronic myelocytic leukemia.
Marketing Status Prescription; Discontinued
ATC Code L01BC01
DrugBank ID DB00987
KEGG ID D00168
MeSH ID D003561
PubChem ID 6253
TTD Drug ID D07XSN
NDC Product Code 67457-452; 68083-343; 58623-0026; 68083-337; 67457-455; 71288-108; 61703-303; 70516-0163; 71288-109; 61703-319; 63323-120; 71288-169; 61703-305; 71288-168; 55512-0026; 61703-304; 12848-1003
Synonyms Cytarabine | Arabinosylcytosine | Cytosine Arabinoside | Arabinoside, Cytosine | Arabinofuranosylcytosine | Aracytidine | beta-Ara C | beta Ara C | Cytarabine Hydrochloride | Cytosar | Cytosar-U | Cytosar U | Ara-C | Ara C | Aracytine | Cytonal
Chemical Information
Molecular Formula C9H13N3O5
CAS Registry Number 147-94-4
SMILES C1=CN(C(=O)N=C1N)C2C(C(C(O2)CO)O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Pain in extremity15.03.04.010--
Pallor24.03.04.001; 08.01.03.032; 23.03.03.0310.000799%Not Available
Palmar-plantar erythrodysaesthesia syndrome23.07.04.001; 17.02.07.0090.001865%
Pancreatitis07.18.01.001--
Pancytopenia01.03.03.0030.014653%Not Available
Papule23.03.03.0380.000533%Not Available
Paraesthesia17.02.06.005--
Paraplegia17.01.04.0070.001332%Not Available
Pelvic pain21.10.01.001; 20.02.03.007; 07.01.06.0120.000533%
Pelvic venous thrombosis24.01.02.0080.000533%Not Available
Pericardial effusion02.06.01.0020.001332%
Pericarditis02.06.02.0010.000799%
Pericarditis constrictive02.06.02.0020.000533%Not Available
Periorbital oedema23.04.01.002; 10.01.05.010; 06.08.03.0170.001066%
Peripheral motor neuropathy17.09.03.004--
Peripheral sensory neuropathy17.09.03.005--
Peritonitis11.01.07.007; 07.19.05.0040.001598%
Personality change19.05.01.006; 17.02.05.019--
Petechiae23.06.01.003; 01.01.03.002; 24.07.06.0040.000799%Not Available
Photophobia17.17.02.006; 06.01.01.0040.000533%
Platelet count decreased13.01.04.0010.004795%
Pleural effusion22.05.02.0020.005328%
Pleurisy22.05.01.0010.000533%Not Available
Pneumonia11.01.09.003; 22.07.01.0030.016784%Not Available
Pneumonia aspiration22.01.01.0050.000139%Not Available
Pneumonia klebsiella22.07.06.001; 11.02.03.0010.000417%Not Available
Pneumonitis22.01.01.0060.001332%
Pneumothorax22.05.02.0030.000533%
Premature baby18.04.02.001--Not Available
Presyncope24.06.02.010; 17.02.05.009; 02.01.02.0070.000799%
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