Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Cytarabine
Drug ID BADD_D00560
Description A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant properties. (From Martindale, The Extra Pharmacopoeia, 30th ed, p472)
Indications and Usage For the treatment of acute non-lymphocytic leukemia, acute lymphocytic leukemia and blast phase of chronic myelocytic leukemia.
Marketing Status Prescription; Discontinued
ATC Code L01BC01
DrugBank ID DB00987
KEGG ID D00168
MeSH ID D003561
PubChem ID 6253
TTD Drug ID D07XSN
NDC Product Code 67457-452; 68083-343; 58623-0026; 68083-337; 67457-455; 71288-108; 61703-303; 70516-0163; 71288-109; 61703-319; 63323-120; 71288-169; 61703-305; 71288-168; 55512-0026; 61703-304; 12848-1003
Synonyms Cytarabine | Arabinosylcytosine | Cytosine Arabinoside | Arabinoside, Cytosine | Arabinofuranosylcytosine | Aracytidine | beta-Ara C | beta Ara C | Cytarabine Hydrochloride | Cytosar | Cytosar-U | Cytosar U | Ara-C | Ara C | Aracytine | Cytonal
Chemical Information
Molecular Formula C9H13N3O5
CAS Registry Number 147-94-4
SMILES C1=CN(C(=O)N=C1N)C2C(C(C(O2)CO)O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Fracture15.08.02.001; 12.04.02.0010.000533%
Fungaemia11.01.11.0020.000139%
Fungal infection11.03.05.0010.003197%Not Available
Gait disturbance17.02.05.016; 08.01.02.002--
Gamma-glutamyltransferase increased13.03.01.0110.000533%
Gastric haemorrhage24.07.02.007; 07.12.01.0010.000799%
Gastrointestinal disorder07.11.01.001--Not Available
Gastrointestinal haemorrhage24.07.02.009; 07.12.02.0010.002664%Not Available
Gastrointestinal necrosis07.15.01.003; 24.04.08.0060.000208%
Generalised oedema14.05.06.007; 08.01.07.0040.000799%
Generalised tonic-clonic seizure17.12.01.0020.000799%Not Available
Gingival bleeding24.07.02.010; 07.09.07.0010.001066%Not Available
Graft versus host disease12.02.09.001; 10.02.01.0270.000139%Not Available
Guillain-Barre syndrome17.09.01.001; 11.07.01.001; 10.04.10.0050.000533%
Haematochezia24.07.02.012; 07.12.02.003--Not Available
Haematoma24.07.01.0010.000799%
Haematuria24.07.01.047; 20.02.01.0060.001066%
Haemoglobin decreased13.01.05.0030.003996%Not Available
Haemoptysis24.07.01.006; 22.02.03.004; 02.01.02.0060.000625%Not Available
Haemorrhage intracranial24.07.04.003; 17.08.01.0080.000764%
Headache17.14.01.001--
Heart rate increased13.14.04.0020.001598%Not Available
Hepatic cirrhosis09.01.04.0010.000278%Not Available
Hepatic failure09.01.03.0020.000417%
Hepatic function abnormal09.01.02.0010.000799%Not Available
Hepatitis09.01.07.0040.001332%Not Available
Hepatocellular injury09.01.07.0080.000533%Not Available
Hepatosplenomegaly09.01.05.002; 01.09.03.0010.000139%Not Available
Hepatotoxicity12.03.01.008; 09.01.07.0090.002131%Not Available
Herpes zoster23.09.03.002; 11.05.02.0030.001066%
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