| Pharmaceutical Information |
| Drug Name |
Cysteamine hydrochloride |
| Drug ID |
BADD_D00558 |
| Description |
Cystinosis is a rare disease caused by mutations in the CTNS gene that encodes for cystinosin, a protein responsible for transporting cystine out of the cell lysosome. A defect in cystinosin function is followed by cystine accumulation throughout the body, especially the eyes and kidneys.[A218721]
Several preparations of cysteamine exist for the treatment of cystinosis manifestations, some in capsule form, and others in ophthalmic solution form.[L15606,L15616] In particular, cystine deposits on the eye can cause significant discomfort throughout the day and require frequent treatment with eye drops, typically every waking hour.[L15611]
On August 25th 2020, the first ophthalmic solution for cystinosis requiring only 4 daily treatments was granted FDA approval.[L15606] Cysteamine eye drops are a practical and effective option for those affected by ocular cystinosis. Marketed by Recordati Rare Diseases Inc., CYSTADROPS® reduce the burden of multiple frequent medications normally administered to those with cystinosis.[L15601] |
| Indications and Usage |
Not Available |
| Marketing Status |
Prescription |
| ATC Code |
S01XA21 |
| DrugBank ID |
DB00847
|
| KEGG ID |
D03635
|
| MeSH ID |
D003543
|
| PubChem ID |
9082
|
| TTD Drug ID |
D0V0LB
|
| NDC Product Code |
17373-1330; 55292-410; 54482-020; 67262-0007 |
| Synonyms |
Cysteamine | beta-Mercaptoethylamine | beta Mercaptoethylamine | Mercaptoethylamine | Mercamine | Mercaptamine | 2-Aminoethanethiol | 2 Aminoethanethiol | Cysteinamine | Cystagon | Cysteamine Bitartrate | Bitartrate, Cysteamine | Cysteamine Tartrate (1:1) | Cysteamine Tartrate | Tartrate, Cysteamine | Cysteamine Dihydrochloride | Dihydrochloride, Cysteamine | Cysteamine Hydrochloride | Hydrochloride, Cysteamine | Cysteamine Maleate (1:1) | Cysteamine Tosylate | Tosylate, Cysteamine | Cysteamine, 35S-Labeled | 35S-Labeled Cysteamine | Cysteamine, 35S Labeled | Becaptan | Cysteamine Hydrobromide | Hydrobromide, Cysteamine |
|
| Chemical Information |
| Molecular Formula |
C2H8ClNS |
| CAS Registry Number |
156-57-0 |
| SMILES |
C(CS)N.Cl |
| Chemical Structure |
|
|
| ADR Related Proteins Induced by Drug |
| ADR Term |
Protein Name |
UniProt AC |
TTD Target ID |
PMID |
| Not Available | Not Available | Not Available | Not Available | Not Available |
|
| ADRs Induced by Drug |
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|
