Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Cyclobenzaprine hydrochloride
Drug ID BADD_D00546
Description Cyclobenzaprine, a centrally-acting muscle relaxant, was first synthesized in 1961[A185039] and has been available for human use since 1977.[A184982] It was initially studied for use as antidepressant given its structural similarity to tricyclic antidepressants - it differs from [Amitriptyline] by only a single double bond.[A185039,A184982] Since its approval, it has remained relatively popular as an adjunctive, short-term treatment for acute skeletal muscle spasms secondary to musculoskeletal injury.
Indications and Usage For use as an adjunct to rest and physical therapy for relief of muscle spasm associated with acute, painful musculoskeletal conditions.
Marketing Status Prescription; Discontinued
ATC Code M03BX08
DrugBank ID DB00924
KEGG ID D00772
MeSH ID C004704
PubChem ID 22576
TTD Drug ID D01KHH
NDC Product Code 60429-876; 70934-063; 62991-1040; 65372-1156; 0115-1436; 72888-014; 67296-1396; 60760-363; 46438-0050; 50090-4024; 71335-1961; 71335-1293; 68071-2659; 50268-190; 50090-4730; 63187-094; 68788-7536; 69306-075; 70934-383; 52817-330; 50090-5712; 0093-1921; 50090-5896; 0115-1437; 70518-0191; 45865-962; 50090-4105; 67296-1343; 63629-2424; 71205-065; 82060-001; 63187-923; 43063-516; 55700-926; 46438-0631; 72789-188; 63629-1210; 50090-5900; 0615-8182; 50090-5256; 55700-696; 72789-156; 53002-0522; 72789-073; 68071-1961; 50090-4722; 67544-251; 61919-537; 70518-2611; 52817-331; 29300-415; 50090-5756; 68788-7445; 50090-4946; 38779-0395; 63629-1213; 61919-064; 76420-168; 43547-400; 51927-0175; 57237-266; 72789-046; 70199-014; 49452-2407; 72789-036; 43547-399; 63629-7653; 63629-1211; 68071-4935; 65015-722; 71205-897; 29300-414; 62332-646; 68071-2453; 80425-0019; 42708-106; 68788-8167; 50090-1848; 68071-4502; 55700-762; 50090-5326; 63629-8983; 63187-157; 71335-1099; 50090-4729; 42708-081; 29300-413; 70518-3251; 71335-0128; 50090-4420; 72189-101; 71335-1962; 50090-5895; 0093-1920; 51655-427; 42291-154; 60505-3973; 59349-0014; 63629-1339; 65977-0030; 71610-379; 71205-454; 62332-649; 63629-1209; 68071-3390; 71335-0096; 72189-283; 0591-5658; 68071-2471; 63187-380; 67296-1763; 24979-036; 59917-090; 68071-3377; 67296-1524; 68981-008; 68071-4826; 55700-925; 71335-1266; 50436-1101; 71335-1253; 71205-059; 62332-647; 53746-541; 63459-701; 71335-0921; 43063-494; 76420-011; 63629-1212; 0093-3422; 70934-442; 10702-006; 71335-1178; 71610-016; 70934-667; 71205-201; 50090-5772; 76420-019; 68084-753; 24979-035; 59746-211; 71610-428; 50090-5897; 68788-9967; 68071-4655; 76420-033; 70518-2788; 65162-541; 72189-080; 71554-116; 63187-342; 71205-132; 72888-013; 45865-433; 76420-030; 50436-0400; 10702-007; 70934-221; 71335-1089; 76420-991; 60760-365; 68071-4951; 0591-3330; 50090-5713; 52817-332; 51927-2501; 61919-261; 76420-010; 67296-1621; 76420-992; 60760-366; 79572-011; 70518-3356; 63629-7803; 16571-783; 66577-013; 65862-190; 65862-191; 0904-7809; 53002-0523; 65162-540; 50090-4727; 63275-9994; 0591-3256; 53296-0003; 69420-1001; 71800-003; 53746-540; 72888-012; 0093-3420; 72189-280; 71205-356; 60505-3972; 66064-1022; 68071-2596; 50090-4026; 67763-107; 0093-3421; 63187-011; 63459-700; 50090-4205; 55700-599; 67296-1534; 59917-091; 45865-801; 63629-7960; 63187-590; 68788-7131; 53002-0520; 72789-115; 59746-177; 63629-8206; 55700-857; 0395-8051; 50436-0006; 68071-4076; 59746-735; 50090-5711; 60429-052; 16571-782; 43063-917; 55700-858; 55154-8143
Synonyms cyclobenzaprine | Flexeril | Lisseril | cyclobenzaprine hydrochloride
Chemical Information
Molecular Formula C20H22ClN
CAS Registry Number 6202-23-9
SMILES CN(C)CCC=C1C2=CC=CC=C2C=CC3=CC=CC=C31.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Abnormal dreams19.02.03.001; 17.15.02.001--Not Available
Acne23.02.01.001--Not Available
Ageusia17.02.07.001; 07.14.03.003--Not Available
Aggression19.05.01.001--Not Available
Agitation19.06.02.001; 17.02.05.012--
Alopecia23.02.02.001--
Anaphylactic reaction10.01.07.001; 24.06.03.006--
Angioedema23.04.01.001; 10.01.05.009--Not Available
Anxiety19.06.02.002--
Arrhythmia02.03.02.001--Not Available
Asthenia08.01.01.001--Not Available
Ataxia17.02.02.001; 08.01.02.004--
Atrioventricular block02.03.01.002--Not Available
Blood glucose decreased13.02.02.001--Not Available
Blood glucose increased13.02.02.002--Not Available
Breast enlargement21.05.04.001--Not Available
Cerebrovascular accident24.03.05.001; 17.08.01.007--
Chest pain08.01.08.002; 02.02.02.011; 22.02.08.003--Not Available
Cholestasis09.01.01.001--Not Available
Confusional state17.02.03.005; 19.13.01.001--
Constipation07.02.02.001--
Delusion19.10.01.001--
Depressed mood19.15.02.001--Not Available
Diarrhoea07.02.01.001--
Diplopia06.02.06.002; 17.17.01.005--Not Available
Disorientation19.13.01.002; 17.02.05.015--Not Available
Disturbance in attention19.21.02.002; 17.03.03.001--
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Dry mouth07.06.01.002--
The 1th Page    1 2 3 4    Next   Last    Total 4 Pages