Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Crizotinib
Drug ID BADD_D00535
Description Crizotinib an inhibitor of receptor tyrosine kinase for the treatment of non-small cell lung cancer (NSCLC). Verification of the presence of ALK fusion gene is done by Abbott Molecular's Vysis ALK Break Apart FISH Probe Kit. This verification is used to select for patients suitable for treatment. FDA approved in August 26, 2011.
Indications and Usage Crizotinib is used for the treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC) that is anaplastic-lymphoma kinase (ALK)-positive as detected by a FDA-approved test.
Marketing Status approved
ATC Code L01ED01
DrugBank ID DB08865
KEGG ID D09731
MeSH ID D000077547
PubChem ID 11626560
TTD Drug ID D03ZBT
NDC Product Code 68724-1020; 53869-2231; 53869-2230; 0069-8140; 0069-8141
UNII 53AH36668S
Synonyms Crizotinib | PF-02341066 | PF-2341066 | PF 2341066 | PF2341066 | PF 02341066 | PF02341066 | Xalkori
Chemical Information
Molecular Formula C21H22Cl2FN5O
CAS Registry Number 877399-52-5
SMILES CC(C1=C(C=CC(=C1Cl)F)Cl)OC2=C(N=CC(=C2)C3=CN(N=C3)C4CCNCC4)N
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Visual field defect17.17.01.001; 06.02.07.0030.003134%Not Available
Visual impairment06.02.10.0130.022453%Not Available
Vitreous detachment12.01.04.005; 06.09.01.0020.000168%Not Available
Vitreous floaters06.09.01.0050.007074%
Vocal cord paralysis22.04.01.002; 17.04.06.0020.000112%
Vomiting07.01.07.0030.028217%
Weight decreased13.15.01.005--
Cardiotoxicity02.11.01.009; 12.03.01.0070.000224%Not Available
Hydrothorax22.05.02.0040.000168%Not Available
Hypoacusis04.02.01.0060.000873%
Seasonal allergy22.04.04.008; 06.04.01.013; 10.01.04.0010.000381%Not Available
Performance status decreased08.01.03.0420.000582%Not Available
Peripheral swelling08.01.03.053; 02.05.04.0150.009111%Not Available
Localised oedema14.05.06.009; 08.01.07.011; 02.05.04.0060.000302%
Brain oedema17.07.02.003; 12.01.10.0100.000280%
Weight fluctuation14.03.02.0020.000112%Not Available
Oesophagitis ulcerative07.04.05.0030.000112%Not Available
Visual brightness17.17.02.009; 06.02.06.0150.000437%Not Available
General physical health deterioration08.01.03.0180.002037%Not Available
Upper respiratory tract inflammation22.12.03.0340.000381%Not Available
Left ventricular dysfunction02.04.02.0110.000112%
Tumour haemorrhage24.07.01.028; 16.32.03.0080.000112%
Balance disorder17.02.02.007; 08.01.03.081--Not Available
Lung cancer metastatic22.08.01.004; 16.19.02.0030.001533%Not Available
Musculoskeletal chest pain22.09.01.001; 15.03.04.0120.000492%
Deep vein thrombosis24.01.02.0030.003100%Not Available
Cardiopulmonary failure22.02.06.004; 02.05.01.0040.000168%Not Available
Malignant neoplasm progression16.16.01.005--Not Available
Eye oedema06.08.03.0130.000302%Not Available
Ocular discomfort06.08.03.0080.000381%Not Available
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ADReCS-Target
Drug Name ADR Term Target
Tip:  Drug Name  ADR Term  Protein  Variation  Gene