Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Crizotinib
Drug ID BADD_D00535
Description Crizotinib an inhibitor of receptor tyrosine kinase for the treatment of non-small cell lung cancer (NSCLC). Verification of the presence of ALK fusion gene is done by Abbott Molecular's Vysis ALK Break Apart FISH Probe Kit. This verification is used to select for patients suitable for treatment. FDA approved in August 26, 2011.
Indications and Usage Crizotinib is used for the treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC) that is anaplastic-lymphoma kinase (ALK)-positive as detected by a FDA-approved test.
Marketing Status approved
ATC Code L01ED01
DrugBank ID DB08865
KEGG ID D09731
MeSH ID D000077547
PubChem ID 11626560
TTD Drug ID D03ZBT
NDC Product Code 68724-1020; 53869-2231; 53869-2230; 0069-8140; 0069-8141
UNII 53AH36668S
Synonyms Crizotinib | PF-02341066 | PF-2341066 | PF 2341066 | PF2341066 | PF 02341066 | PF02341066 | Xalkori
Chemical Information
Molecular Formula C21H22Cl2FN5O
CAS Registry Number 877399-52-5
SMILES CC(C1=C(C=CC(=C1Cl)F)Cl)OC2=C(N=CC(=C2)C3=CN(N=C3)C4CCNCC4)N
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Retinal detachment06.09.03.003; 12.01.04.0040.000280%
Sarcoma16.33.01.002; 15.09.03.0020.000112%Not Available
Sciatica17.10.03.001; 15.10.01.0010.000246%Not Available
Second primary malignancy16.16.01.0140.001343%
Sepsis11.01.11.003--
Septic shock24.06.02.011; 11.01.11.004--Not Available
Shock24.06.02.002--Not Available
Sinus bradycardia02.03.03.0090.000616%
Skin disorder23.03.03.007--Not Available
Small intestinal perforation07.04.06.0060.000112%
Squamous cell carcinoma of skin16.03.02.005; 23.08.02.0050.000112%Not Available
Stomatitis07.05.06.005--
Sudden death08.04.01.003; 02.03.04.0130.000224%
Swelling08.01.03.0150.005339%Not Available
Syncope24.06.02.012; 02.11.04.015; 17.02.04.008--
Throat irritation22.12.03.029; 07.05.05.0370.001198%Not Available
Thrombocytopenia01.08.01.002--Not Available
Tongue disorder07.14.01.0020.000437%Not Available
Toothache07.09.06.0010.000246%
Tricuspid valve incompetence02.07.05.0010.000112%Not Available
Tumour lysis syndrome16.32.03.002; 14.05.01.0040.000168%
Tunnel vision17.17.01.013; 06.02.07.0050.000112%Not Available
Ulcer08.03.06.0010.000224%Not Available
Upper respiratory tract infection22.07.03.011; 11.01.13.009--
Urethral disorder20.07.01.002--Not Available
Urinary tract disorder20.08.01.001--Not Available
Uterine cancer16.12.05.001; 21.07.02.0030.000112%Not Available
Uveitis06.04.03.003; 10.02.01.0230.000168%
Vision blurred17.17.01.010; 06.02.06.0070.009256%
Visual acuity reduced06.02.10.012; 17.17.01.0110.000795%
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ADReCS-Target
Drug Name ADR Term Target
Tip:  Drug Name  ADR Term  Protein  Variation  Gene