Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Colchicine
Drug ID BADD_D00518
Description First approved by the FDA in 1961, colchicine is an alkaloid drug commonly used in the management of gout, a condition associated with the painful deposition of urate crystals in the joints.[A183614,L8138] It is derived from a plant belonging to the Lily family, known as Colchicum autumnale, or "autumn crocus".[A183611] Other than its use in gout, colchicine has been approved for managing exacerbations of Familial Mediterranean Fever (FMF), a hereditary autoinflammatory condition.[A186320,L8141]
Indications and Usage For treatment and relief of pain in attacks of acute gouty arthritis.
Marketing Status Prescription
ATC Code M04AC01
DrugBank ID DB01394
KEGG ID D00570
MeSH ID D003078
PubChem ID 6167
NDC Product Code 75854-801; 0378-1086; 0591-2562; 68071-2567; 55742-127; 49452-2210; 43353-854; 43598-372; 63629-2167; 63629-8362; 70710-1351; 50268-187; 66064-1008; 59651-455; 59467-318; 64764-119; 31722-899; 63187-292; 65162-710; 72189-331; 72189-249; 63629-7422; 47234-0119; 0254-2008; 17359-5000; 0143-3018; 0904-7120; 16714-039; 63629-2166; 63629-8766; 70771-1590; 0904-6732; 61281-3600; 69037-0011; 71205-310; 71335-1802; 71610-494; 51927-1895; 68404-0001; 67296-1708; 60687-358; 72643-009; 70771-1396; 67877-589; 51407-082; 42292-054; 70010-002; 71335-1695; 70710-1571; 71335-1738; 60687-389
Synonyms Colchicine | Colchicine, (R)-Isomer | Colchicine, (+-)-Isomer
Chemical Information
Molecular Formula C22H25NO6
CAS Registry Number 64-86-8
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.0010.000571%Not Available
Abdominal pain07.01.05.0020.000571%
Abdominal pain upper07.01.05.0030.000571%
Acute respiratory distress syndrome22.01.03.001--
Agranulocytosis01.02.03.001--Not Available
Alanine aminotransferase increased13.03.01.003--
Angioedema23.04.01.001; Available
Anuria20.01.03.002--Not Available
Aplastic anaemia01.03.03.002--Not Available
Aspartate aminotransferase increased13.03.01.006--
Asthenia08.01.01.0010.001428%Not Available
Axonal neuropathy17.09.03.015--Not Available
Bladder pain20.02.02.001--Not Available
Blood creatine phosphokinase increased13.04.01.001--
Blood creatinine increased13.13.01.004--
Cardiac failure congestive02.05.01.0020.000571%Not Available
Dermatitis23.03.04.002--Not Available
Disseminated intravascular coagulation24.01.01.010;
Eye disorder06.08.03.001--Not Available
Gastrointestinal disorder07.11.01.001--Not Available
Gastrointestinal haemorrhage24.07.02.009; Available
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