Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Codeine
Drug ID BADD_D00516
Description The relief of pain (analgesia) is a primary goal for enhancing the quality of life of patients and for increasing the ability of patients to engage in day to day activities. Codeine, an opioid analgesic, was originally approved in the US in 1950 and is a drug used to decrease pain by increasing the threshold for pain without impairing consciousness or altering other sensory functions. Opiates such as codeine are derived from the poppy plant, _Papaver somniferum_ (Papaveraceae).[A175096] Codeine is utilized as a central analgesic, sedative, hypnotic, antinociceptive, and antiperistaltic agent, and is also recommended in certain diseases with incessant coughing.[LABEL,A175096]
Indications and Usage For treatment and management of pain (systemic). It is also used as an antidiarrheal and as a cough suppressant.
Marketing Status Not Available
ATC Code R05DA04
DrugBank ID DB00318
KEGG ID C06174
MeSH ID D003061
PubChem ID 5284371
NDC Product Code Not Available
Synonyms Codeine | Morphinan-6-ol, 7,8-didehydro-4,5-epoxy-3-methoxy-17-methyl-, (5alpha,6alpha)- | N-Methylmorphine | N Methylmorphine | Isocodeine | Codeine Phosphate | Ardinex
Chemical Information
Molecular Formula C18H21NO3
CAS Registry Number 76-57-3
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Depressed level of consciousnessCytochrome P450 2D6P10635T5739210772431; 15748098; 10983742
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.0010.007657%Not Available
Abdominal pain07.01.05.002--
Anaphylactic reaction24.06.03.006;
Angioedema23.04.01.001; Available
Asthenia08.01.01.001--Not Available
Biliary colic09.02.01.001--Not Available
Body temperature decreased13.15.01.010--Not Available
Body temperature increased13.15.01.001--Not Available
Bone disorder15.02.04.004--Not Available
Bradycardia02.03.02.002--Not Available
Cardiac arrest02.03.04.001--
Cardio-respiratory arrest22.02.06.007; Available
Chest pain02.02.02.011;; Available
Coma17.02.09.0010.000399%Not Available
Completed suicide19.12.01.001; Available
Confusional state17.02.03.005;
Depressed level of consciousness17.02.04.0020.002297%
Dermatitis23.03.04.002--Not Available
Diplopia17.17.01.005; Available
Discomfort08.01.08.003--Not Available
Drug abuse19.07.02.0100.006192%Not Available
Drug hypersensitivity10.01.01.0010.123277%Not Available
Drug withdrawal syndrome19.07.02.011; Available
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