Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Clozapine
Drug ID BADD_D00511
Description A tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent.
Indications and Usage For use in patients with treatment-resistant schizophrenia.
Marketing Status Prescription; Discontinued
ATC Code N05AH02
DrugBank ID DB00363
KEGG ID D00283
MeSH ID D003024
PubChem ID 135398737
TTD Drug ID D0Z1RV
NDC Product Code 57664-345; 0904-7088; 16729-141; 71554-025; 0093-3086; 51079-921; 55154-3568; 60687-404; 0378-3815; 51407-086; 0093-3087; 52817-601; 76072-1010; 0378-0972; 60687-548; 51862-274; 60429-989; 64374-004; 70518-3391; 12828-0072; 0378-0825; 60687-415; 53296-0033; 65862-846; 57664-241; 55154-8285; 57664-347; 65015-706; 60429-990; 51862-901; 0378-3813; 51407-085; 63552-062; 63629-2360; 69809-0126; 60687-426; 63629-2361; 72721-1725; 72721-1760; 0093-4404; 0904-7089; 67835-0028; 65862-847; 16729-142; 0378-0860; 57664-211; 51862-903; 0093-7772; 51862-273; 65862-844; 51079-749; 51079-922; 0093-5377; 0904-7087; 63629-2362; 65862-845; 70518-3357; 63552-063; 0093-5416; 69809-0130; 72721-1750; 51079-288; 72721-1770; 0093-4359; 0093-5419; 69809-0127; 0093-5376; 69809-0135; 63629-2359; 0378-0973; 73377-150; 51862-902; 0093-5417; 0093-4405; 51862-900
Synonyms Clozapine | Clozaril | Leponex
Chemical Information
Molecular Formula C18H19ClN4
CAS Registry Number 5786-21-0
SMILES CN1CCN(CC1)C2=NC3=C(C=CC(=C3)Cl)NC4=CC=CC=C42
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Tardive dyskinesiaD(2) dopamine receptorP14416T6716210821369; 10379516; 10893495; 9777180; 10889553
Tardive dyskinesiaD(3) dopamine receptorP35462T0255110821369; 10379516; 10893495; 9777180; 10889553
Tardive dyskinesiaD(4) dopamine receptorP21917T2498310821369; 10379516; 10893495; 9777180; 10889553
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Breast abscess21.05.03.003; 18.06.02.002; 11.01.02.0020.014012%Not Available
Breast cancer21.05.01.003; 16.10.01.0010.193366%Not Available
Breast cancer stage IV21.05.01.010; 16.10.01.0030.002193%Not Available
Breast cyst16.14.01.004; 21.05.01.0060.005605%Not Available
Breast enlargement21.05.04.001--Not Available
Breast mass21.05.04.0020.003655%Not Available
Breast pain21.05.05.003--
Bronchiectasis22.03.02.0050.008407%Not Available
Bronchitis22.07.01.001; 11.01.09.001--
Bronchospasm22.03.01.004; 10.01.03.012--
Bruxism19.11.03.001; 07.01.06.008--Not Available
Budd-Chiari syndrome24.01.03.001; 09.01.06.0010.005605%
Bulimia nervosa19.09.01.006; 14.03.03.0010.005605%Not Available
Bundle branch block left02.03.01.0070.056048%Not Available
Bundle branch block right02.03.01.0110.067258%Not Available
Burkitt's lymphoma16.28.04.001; 01.15.04.0010.005848%Not Available
Burning sensation17.02.06.001; 08.01.09.029--Not Available
Bursitis15.04.01.001--Not Available
C-reactive protein increased13.09.01.0070.557678%Not Available
Cachexia08.01.01.009; 16.32.03.011; 14.03.02.001--Not Available
Carbon dioxide decreased13.02.01.0120.011210%Not Available
Cardiac arrest02.03.04.0010.079686%
Cardiac failure02.05.01.001--
Cardiac failure acute02.05.01.005--Not Available
Cardiac failure congestive02.05.01.002--Not Available
Cardiac murmur13.14.01.001--Not Available
Cardiac tamponade02.06.01.001--
Cardio-respiratory arrest22.02.06.007; 02.03.04.002--Not Available
Cardiogenic shock24.06.02.006; 02.05.01.003--Not Available
Cardiomegaly02.04.02.0010.011697%Not Available
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