Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Clozapine
Drug ID BADD_D00511
Description A tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent.
Indications and Usage For use in patients with treatment-resistant schizophrenia.
Marketing Status Prescription; Discontinued
ATC Code N05AH02
DrugBank ID DB00363
KEGG ID D00283
MeSH ID D003024
PubChem ID 135398737
TTD Drug ID D0Z1RV
NDC Product Code 57664-345; 0904-7088; 16729-141; 71554-025; 0093-3086; 51079-921; 55154-3568; 60687-404; 0378-3815; 51407-086; 0093-3087; 52817-601; 76072-1010; 0378-0972; 60687-548; 51862-274; 60429-989; 64374-004; 70518-3391; 12828-0072; 0378-0825; 60687-415; 53296-0033; 65862-846; 57664-241; 55154-8285; 57664-347; 65015-706; 60429-990; 51862-901; 0378-3813; 51407-085; 63552-062; 63629-2360; 69809-0126; 60687-426; 63629-2361; 72721-1725; 72721-1760; 0093-4404; 0904-7089; 67835-0028; 65862-847; 16729-142; 0378-0860; 57664-211; 51862-903; 0093-7772; 51862-273; 65862-844; 51079-749; 51079-922; 0093-5377; 0904-7087; 63629-2362; 65862-845; 70518-3357; 63552-063; 0093-5416; 69809-0130; 72721-1750; 51079-288; 72721-1770; 0093-4359; 0093-5419; 69809-0127; 0093-5376; 69809-0135; 63629-2359; 0378-0973; 73377-150; 51862-902; 0093-5417; 0093-4405; 51862-900
Synonyms Clozapine | Clozaril | Leponex
Chemical Information
Molecular Formula C18H19ClN4
CAS Registry Number 5786-21-0
SMILES CN1CCN(CC1)C2=NC3=C(C=CC(=C3)Cl)NC4=CC=CC=C42
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Tardive dyskinesiaD(2) dopamine receptorP14416T6716210821369; 10379516; 10893495; 9777180; 10889553
Tardive dyskinesiaD(3) dopamine receptorP35462T0255110821369; 10379516; 10893495; 9777180; 10889553
Tardive dyskinesiaD(4) dopamine receptorP21917T2498310821369; 10379516; 10893495; 9777180; 10889553
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Pneumococcal sepsis11.02.06.0070.002924%Not Available
Clostridium difficile infection11.02.02.009--Not Available
Mean platelet volume increased13.01.04.0140.003655%Not Available
Oesophageal cancer metastatic16.13.06.003; 07.21.06.0030.001462%Not Available
Breast cancer metastatic21.05.01.016; 16.10.01.0080.013890%Not Available
Colon cancer metastatic16.13.01.012; 07.21.01.0100.002924%Not Available
Autoimmune neutropenia01.02.03.013; 10.04.01.0100.005605%Not Available
Infective exacerbation of chronic obstructive airways disease22.03.01.022; 11.01.09.0150.008407%Not Available
Eosinophilic colitis07.08.01.019; 01.02.04.0150.011210%Not Available
Bifascicular block02.03.01.0200.005605%Not Available
Aortic dilatation24.03.04.0070.008407%Not Available
Ovarian cancer metastatic21.11.01.013; 16.12.04.0040.001462%Not Available
Computerised tomogram thorax abnormal13.19.02.0050.005605%Not Available
Anticonvulsant drug level decreased13.17.01.0240.005605%Not Available
Gastrointestinal oedema07.11.01.0120.005605%Not Available
Troponin T increased13.04.01.0150.072862%
Parakeratosis23.03.03.0670.008407%Not Available
Cardiac function test abnormal13.14.02.0060.005605%Not Available
Total cholesterol/HDL ratio increased13.12.01.0070.001462%Not Available
Negative thoughts19.15.02.012--Not Available
Sopor19.02.04.002; 17.02.04.0210.140120%Not Available
Abdominal compartment syndrome24.04.09.009; 07.11.01.0170.002924%Not Available
Psychogenic seizure19.24.01.0070.008407%Not Available
General physical condition abnormal13.15.01.0400.263426%Not Available
Small cell lung cancer metastatic22.08.01.012; 16.19.08.0020.002193%Not Available
Blood alkaline phosphatase decreased13.04.02.0030.008407%Not Available
Antipsychotic drug level above therapeutic13.17.01.0270.145725%Not Available
Antipsychotic drug level below therapeutic13.17.01.0280.112096%Not Available
Diabetic foot24.04.03.015; 23.07.03.008; 17.09.04.006; 14.07.06.001; 05.07.06.0010.005605%Not Available
Catecholamines urine increased13.10.01.0040.005605%Not Available
The 46th Page    First    Pre   46 47 48    Next   Last    Total 48 Pages