Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Clotrimazole
Drug ID BADD_D00509
Description This drug is a broad spectrum antimycotic or antifungal agent. Clotrimazole's antimycotic properties were discovered in the late 1960s [A174094]. Clotrimazole falls under the _imidazole_ category of _azole_ antifungals, possessing broad-spectrum antimycotic activity [A174094]. It is available in various preparations, including creams, pessaries, and troche formulations (slowly dissolving tablets). As well as its antifungal activity, clotrimazole has become a drug of interest in treating several other diseases such as sickle cell disease, malaria and some cancers [A174094]. The minimal side effect profile of this drug and its uncomplicated metabolic profile have led it to gain widespread acceptance for the treatment of mycotic outbreaks such as vaginal yeast infections as well as athlete's foot [A174097].
Indications and Usage For the local treatment of oropharyngeal candidiasis and vaginal yeast infections, also used in fungal infections of the skin such as ringworm, athlete's foot, and jock itch.
Marketing Status Prescription; OTC; Discontinued
ATC Code A01AB18; D01AC01; G01AF02
DrugBank ID DB00257
KEGG ID D00282
MeSH ID D003022
PubChem ID 2812
TTD Drug ID D09GOS
NDC Product Code 36800-508; 55301-857; 41163-963; 62512-0066; 24385-110; 11822-3078; 55315-008; 52261-5801; 71205-434; 50090-2570; 68927-3490; 68784-301; 11822-1110; 0295-6307; 63187-501; 68071-4800; 70000-0542; 73538-001; 50382-025; 62512-0064; 70673-747; 0363-2062; 69842-866; 0536-1181; 50090-0614; 24909-104; 68016-859; 79503-105; 52410-3024; 0363-1857; 49706-0545; 79481-0014; 21130-287; 69396-001; 0363-3492; 10135-671; 54633-314; 0113-0857; 11673-062; 49035-253; 51672-1260; 68071-2614; 49706-1545; 21130-210; 59779-305; 11822-0350; 54473-096; 50090-0524; 68788-7682; 24909-207; 36800-495; 68788-7402; 47832-071; 24909-106; 70795-8020; 71205-438; 0472-0220; 49035-812; 68981-045; 51552-0138; 69070-303; 76003-0329; 0904-7822; 62991-1035; 61360-2037; 30142-510; 69848-001; 59779-514; 0054-8146; 80684-039; 62512-0044; 54633-018; 68462-181; 36800-857; 51672-2037; 11523-1125; 70000-0493; 68071-2469; 50066-111; 0295-1363; 50090-0562; 55621-003; 59088-476; 63187-559; 68071-4225; 69842-062; 41520-305; 63868-690; 11822-0351; 59088-441; 45802-434; 0168-0133; 55614-650; 0395-8224; 49452-2148; 11822-0220; 0054-4146; 48087-0088; 11527-071; 70518-3396; 13746-104; 17337-0512; 11523-6549; 67510-0657; 49964-0014; 24909-208; 67234-009; 50090-4971; 63868-259; 62512-0060; 67234-014; 68788-8091; 71205-432; 0472-0350; 0536-1272; 70518-2932; 49348-793; 52389-647; 21130-870; 49035-837; 51824-063; 0363-0220; 73921-014; 50090-1770; 24909-203; 51672-1275; 37808-305; 11673-910; 72127-0801; 71399-0500; 61269-220; 52389-733; 68071-3395; 24385-205; 68071-2317; 67091-196; 43285-0043; 52389-600; 30142-305; 24909-212; 50090-5931; 49348-279; 50804-143; 48087-0086; 0536-1265; 0574-0107; 11523-0963; 38779-0019; 0363-2107; 41415-056; 51672-2062; 24909-102; 70518-0207; 65923-052; 48087-0084; 24885-777; 0363-2105; 51672-2002; 13630-0092; 66977-023; 53002-8400; 68788-9665; 49348-379; 68071-2315; 53943-990; 11673-504; 11673-857; 68016-414; 59779-712; 50090-1522; 67510-0638; 51672-2003; 66267-980; 79572-010; 0363-2109; 68071-4026; 53002-9080; 20276-105; 71399-0501; 41250-745; 68016-035
Synonyms Clotrimazole | Klotrimazole | Mycelex | FB b 5097 | Lotrimin | Bay b 5097 | Canesten | Kanesten
Chemical Information
Molecular Formula C22H17ClN2
CAS Registry Number 23593-75-1
SMILES C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3Cl)N4C=CN=C4
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Pyrexia08.05.02.0030.000689%
Rash23.03.13.0010.001379%Not Available
Skin exfoliation23.03.07.003--Not Available
Skin irritation23.03.04.009--Not Available
Tachycardia02.03.02.0070.000689%Not Available
Urticaria23.04.02.001; 10.01.06.001--
Vaginal haemorrhage24.07.03.005; 21.08.01.0010.001724%
Vomiting07.01.07.003--
Vulvovaginal discomfort21.08.02.0050.000689%Not Available
Vanishing bile duct syndrome09.02.03.0030.000689%Not Available
Haemorrhage24.07.01.002--Not Available
Cystitis noninfective20.03.02.001--
Vulvovaginal burning sensation21.08.02.007--Not Available
Vulvovaginal pain21.08.02.0090.000689%
Vulvovaginal swelling21.08.02.0160.000689%Not Available
Drug-induced liver injury09.01.07.023; 12.03.01.0440.000689%Not Available
The 2th Page    First    Pre   2    Total 2 Pages