Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Clopidogrel
Drug ID BADD_D00504
Description Clopidogrel is a prodrug of a platelet inhibitor used to reduce the risk of myocardial infarction and stroke.[A180508,L7213] Clopidogrel is indicated to reduce the risk of myocardial infarction for patients with non-ST elevated acute coronary syndrome (ACS), patients with ST-elevated myocardial infarction, and in recent MI, stroke, or established peripheral arterial disease,[L7213] It has been shown to be superior to [aspirin] in reducing cardiovascular outcomes in patients with cardiovascular disease and provides additional benefit to patients with acute coronary syndromes already taking aspirin.[A180547] Clopidogrel was granted FDA approval on 17 November 1997.[L7213]
Indications and Usage For the reduction of atherosclerotic events (myocardial infarction, stroke, and vascular death) in patients with atherosclerosis documented by recent stroke, recent myocardial infarction, or established peripheral arterial disease.
Marketing Status Prescription; Discontinued
ATC Code B01AC04
DrugBank ID DB00758
KEGG ID D07729
MeSH ID D000077144
PubChem ID 60606
TTD Drug ID D0N0TZ
NDC Product Code 65977-0037; 0093-7314; 16729-218; 42543-713; 71335-1409; 42543-714; 65162-414; 68788-7645; 52605-083; 50090-5781; 50090-4918; 70518-0400; 61919-737; 52605-082; 63653-1171; 0024-1332; 63187-362; 70934-708; 61919-007; 33342-060; 68071-1578; 70771-1062; 68071-4138; 71335-0581; 63629-4728; 16729-219; 63653-1332; 0024-1171; 72578-012
Synonyms Clopidogrel | SC 25989C | SC 25990C | SR 25989 | Clopidogrel-Mepha | Clopidogrel Mepha | Clopidogrel Sandoz | Iscover | Clopidogrel Napadisilate | Clopidogrel Hydrochloride | PCR 4099 | PCR-4099 | Clopidogrel Besylate | Clopidogrel Besilate | Clopidogrel, (+)(S)-isomer | Plavix | Clopidogrel Bisulfate
Chemical Information
Molecular Formula C16H16ClNO2S
CAS Registry Number 113665-84-2
SMILES COC(=O)C(C1=CC=CC=C1Cl)N2CCC3=C(C2)C=CS3
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Apparent death08.01.03.0620.000098%Not Available
Dieulafoy's vascular malformation24.03.03.025; 07.15.04.0020.000147%Not Available
Haemorrhagic hepatic cyst24.07.01.070; 16.06.02.003; 09.01.08.0130.000098%Not Available
Pharyngeal haematoma22.04.05.016; 24.07.02.0550.000245%Not Available
Respiratory fatigue22.02.08.0190.000098%Not Available
Basal ganglia infarction17.08.01.040; 24.04.06.0280.000147%Not Available
Brain midline shift17.11.01.0110.000051%Not Available
Inflammatory marker increased13.09.02.0030.000098%Not Available
Gastrointestinal vascular malformation24.03.03.031; 07.15.04.0070.000245%Not Available
Lip pruritus07.05.05.0210.000147%Not Available
False negative investigation result13.18.01.0060.000098%Not Available
Psychological trauma19.01.02.0170.000294%Not Available
Infectious pleural effusion22.05.01.004; 11.01.09.0110.000098%Not Available
Parinaud syndrome17.17.02.013; 06.05.02.0230.000245%Not Available
Oesophageal mucosal dissection07.11.02.0070.000147%Not Available
Obstructive shock24.06.02.024; 02.05.01.0130.000245%Not Available
Large intestinal stenosis07.13.03.0040.000098%
Gastrointestinal polyp haemorrhage24.07.02.046; 16.05.03.003; 07.20.01.0110.000196%Not Available
Traumatic haemothorax24.07.01.085; 22.05.02.008; 12.01.03.0100.000077%Not Available
Spontaneous haemorrhage24.07.01.081; 01.01.03.0070.000294%Not Available
Internal haemorrhage24.07.01.0720.000294%Not Available
Thunderclap headache17.14.01.0180.000026%Not Available
Unmasking of previously unidentified disease08.01.03.0800.001717%Not Available
Chest wall haematoma24.07.01.065; 15.03.01.0230.000098%Not Available
Lacunar stroke24.04.06.037; 17.08.01.0540.000294%Not Available
Vascular stent occlusion24.04.02.026; 08.07.05.0050.000098%Not Available
Vascular stent stenosis24.04.02.028; 08.07.05.0070.000245%Not Available
Vascular stent restenosis24.04.02.027; 08.07.05.0060.000196%Not Available
Oesophageal intramural haematoma24.07.02.050; 07.12.01.0060.000294%Not Available
Left-to-right cardiac shunt02.04.02.031; 03.07.02.0060.000245%Not Available
The 36th Page    First    Pre   36    Total 36 Pages