Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Clopidogrel
Drug ID BADD_D00504
Description Clopidogrel is a prodrug of a platelet inhibitor used to reduce the risk of myocardial infarction and stroke.[A180508,L7213] Clopidogrel is indicated to reduce the risk of myocardial infarction for patients with non-ST elevated acute coronary syndrome (ACS), patients with ST-elevated myocardial infarction, and in recent MI, stroke, or established peripheral arterial disease,[L7213] It has been shown to be superior to [aspirin] in reducing cardiovascular outcomes in patients with cardiovascular disease and provides additional benefit to patients with acute coronary syndromes already taking aspirin.[A180547] Clopidogrel was granted FDA approval on 17 November 1997.[L7213]
Indications and Usage For the reduction of atherosclerotic events (myocardial infarction, stroke, and vascular death) in patients with atherosclerosis documented by recent stroke, recent myocardial infarction, or established peripheral arterial disease.
Marketing Status Prescription; Discontinued
ATC Code B01AC04
DrugBank ID DB00758
KEGG ID D07729
MeSH ID D000077144
PubChem ID 60606
TTD Drug ID D0N0TZ
NDC Product Code 65977-0037; 0093-7314; 16729-218; 42543-713; 71335-1409; 42543-714; 65162-414; 68788-7645; 52605-083; 50090-5781; 50090-4918; 70518-0400; 61919-737; 52605-082; 63653-1171; 0024-1332; 63187-362; 70934-708; 61919-007; 33342-060; 68071-1578; 70771-1062; 68071-4138; 71335-0581; 63629-4728; 16729-219; 63653-1332; 0024-1171; 72578-012
Synonyms Clopidogrel | SC 25989C | SC 25990C | SR 25989 | Clopidogrel-Mepha | Clopidogrel Mepha | Clopidogrel Sandoz | Iscover | Clopidogrel Napadisilate | Clopidogrel Hydrochloride | PCR 4099 | PCR-4099 | Clopidogrel Besylate | Clopidogrel Besilate | Clopidogrel, (+)(S)-isomer | Plavix | Clopidogrel Bisulfate
Chemical Information
Molecular Formula C16H16ClNO2S
CAS Registry Number 113665-84-2
SMILES COC(=O)C(C1=CC=CC=C1Cl)N2CCC3=C(C2)C=CS3
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Gastrointestinal erosion07.04.04.0090.000245%Not Available
Myxoedema coma17.02.09.009; 14.11.01.042; 05.02.03.0060.000147%Not Available
Embolic cerebral infarction24.01.04.009; 17.08.01.0290.000026%Not Available
Arterial haemorrhage24.07.01.0630.000491%Not Available
Arterial stenosis24.04.02.0120.000147%Not Available
Cerebellar haematoma24.07.04.022; 17.08.01.0450.000038%Not Available
Communication disorder19.19.01.0080.000147%Not Available
Gastric mucosal lesion07.11.03.0070.000147%Not Available
Skull fracture15.08.04.002; 12.04.05.0030.000038%Not Available
Traumatic intracranial haemorrhage24.07.04.034; 17.08.05.005; 12.01.10.0170.000038%Not Available
Platelet function test abnormal13.01.04.0060.000294%Not Available
Deformity08.01.03.0220.000491%Not Available
Angiodysplasia24.03.03.0170.000098%Not Available
Heart valve stenosis02.07.02.0070.000098%Not Available
Small intestinal stenosis07.13.06.0080.000098%
Erosive duodenitis07.04.02.0060.000147%Not Available
Tracheal haemorrhage24.07.01.084; 22.04.07.009; 12.02.07.0130.000196%
Acute right ventricular failure02.05.03.0030.000196%Not Available
Basilar artery thrombosis24.01.04.014; 17.08.01.0430.000245%Not Available
Renal embolism20.01.07.014; 24.01.11.0030.000098%Not Available
Cerebral hyperperfusion syndrome24.03.05.011; 17.08.02.018; 12.02.01.0210.000343%Not Available
Breast haematoma24.07.03.020; 21.05.05.0130.000098%Not Available
Eyelid haematoma24.07.05.013; 12.01.04.025; 23.06.07.007; 06.07.05.0020.000294%Not Available
Gastric fistula12.02.03.018; 07.11.05.0110.000098%
Basal ganglia haemorrhage24.07.04.021; 17.08.01.0390.000051%Not Available
Carotid arteriosclerosis24.04.06.031; 17.08.02.0150.000098%Not Available
Vasogenic cerebral oedema17.07.02.0080.000098%Not Available
Left atrial dilatation02.04.02.0250.000098%Not Available
Thrombotic cerebral infarction24.01.04.017; 17.08.01.0630.000098%Not Available
Abdominal wall haematoma24.07.02.039; 07.16.05.0050.000883%Not Available
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