ADReCS

Pharmaceutical Information

Drug Name	Clopidogrel
Drug ID	BADD_D00504
Description	Clopidogrel is a prodrug of a platelet inhibitor used to reduce the risk of myocardial infarction and stroke.[A180508,L7213] Clopidogrel is indicated to reduce the risk of myocardial infarction for patients with non-ST elevated acute coronary syndrome (ACS), patients with ST-elevated myocardial infarction, and in recent MI, stroke, or established peripheral arterial disease,[L7213] It has been shown to be superior to [aspirin] in reducing cardiovascular outcomes in patients with cardiovascular disease and provides additional benefit to patients with acute coronary syndromes already taking aspirin.[A180547] Clopidogrel was granted FDA approval on 17 November 1997.[L7213]
Indications and Usage	Clopidogrel is indicated to reduce the risk of myocardial infarction for patients with non-ST elevated acute coronary syndrome (ACS), patients with ST-elevated myocardial infarction, and in recent MI, stroke, or established peripheral arterial disease,[L7213]
Marketing Status	approved
ATC Code	B01AC04
DrugBank ID	DB00758
KEGG ID	D07729; D10823; D10824
MeSH ID	D000077144
PubChem ID	60606
TTD Drug ID	D0N0TZ
NDC Product Code	42543-714; 50090-4918; 52605-083; 16729-218; 0024-1171; 68788-8190; 72578-012; 65977-0037; 52605-082; 63187-362; 63629-4728; 70518-0400; 33342-060; 42543-713; 65162-414; 0093-7314; 16729-219; 61919-007; 67296-1840; 50090-2598; 50090-5781; 0024-1332; 61919-737; 70771-1062; 16714-052; 68071-2813; 68071-4138; 71335-0581
UNII	A74586SNO7
Synonyms	Clopidogrel \| SC 25989C \| SC 25990C \| SR 25989 \| Clopidogrel-Mepha \| Clopidogrel Mepha \| Clopidogrel Sandoz \| Iscover \| Clopidogrel Napadisilate \| Clopidogrel Hydrochloride \| PCR 4099 \| PCR-4099 \| Clopidogrel Besylate \| Clopidogrel Besilate \| Clopidogrel, (+)(S)-isomer \| Plavix \| Clopidogrel Bisulfate

Chemical Information

Molecular Formula	C16H16ClNO2S
CAS Registry Number	113665-84-2
SMILES	COC(=O)C(C1=CC=CC=C1Cl)N2CCC3=C(C2)C=CS3
Chemical Structure

ADRs Induced by Drug

*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..

ADR Term	ADReCS ID	ADR Frequency (FAERS)	ADR Severity Grade (FAERS)	ADR Severity Grade (CTCAE)
Gastrointestinal angiodysplasia	24.03.03.007; 07.15.04.001	0.000053%		Not Available
Haemorrhagic cerebral infarction	24.07.04.026; 17.08.01.050	0.000032%		Not Available
Haemorrhagic infarction	24.04.02.008	0.000043%		Not Available
Haemosiderosis	14.13.03.004; 12.02.08.007	0.000021%		Not Available
Hepatic haematoma	12.01.17.008; 24.07.01.071; 09.01.06.016	0.000032%		Not Available
Jejunal ulcer	07.04.06.012	0.000021%
Lung adenocarcinoma	22.08.01.007; 16.19.01.002	0.000021%		Not Available
Lymphadenopathy mediastinal	22.09.03.006; 01.09.01.025	0.000032%		Not Available
Mesenteric arterial occlusion	24.04.08.003; 07.15.02.002	0.000032%		Not Available
Mesenteric vein thrombosis	07.15.02.013; 24.01.08.004	0.000021%		Not Available
Oesophageal ulcer haemorrhage	24.07.02.051; 07.04.05.007	0.000021%		Not Available
Rectal perforation	07.04.01.004	0.000107%
Renal haematoma	24.07.07.004; 20.01.02.018; 12.01.05.006	0.000021%		Not Available
Ruptured cerebral aneurysm	24.02.04.005; 17.08.01.059	0.000021%		Not Available
Splenic haemorrhage	01.09.02.015; 12.01.17.020; 24.07.01.080	0.000021%		Not Available
Throat cancer	22.08.02.008; 16.19.02.007	0.000058%		Not Available
Tongue haematoma	24.07.02.057; 07.14.01.014	0.000043%		Not Available
Urinary bladder haemorrhage	24.07.01.086; 20.03.01.023	0.000032%		Not Available
Aneurysm ruptured	24.02.01.002	0.000032%		Not Available
Endothelial dysfunction	24.03.02.028	0.000043%		Not Available
Atrial thrombosis	02.11.01.002; 24.01.05.005	0.000043%		Not Available
Tongue haemorrhage	24.07.02.058; 07.14.01.015	0.000122%		Not Available
Mediastinal haematoma	24.07.01.074; 22.09.03.007	0.000053%		Not Available
Spinal subdural haematoma	24.07.04.032; 17.08.01.060; 12.01.13.008	0.000032%		Not Available
Carotid aneurysm rupture	24.02.04.002; 17.08.01.044	0.000021%		Not Available
Small intestinal haemorrhage	24.07.02.019; 07.12.03.002	0.000053%
Meningorrhagia	24.07.04.030; 17.08.01.056; 12.01.10.016	0.000021%		Not Available
Cardiac ventricular thrombosis	02.11.01.008; 24.01.05.006	0.000032%		Not Available
Pulmonary haematoma	22.12.01.008; 24.07.01.077	0.000032%		Not Available
Hepatic ischaemia	24.04.07.008; 09.01.06.018	0.000021%		Not Available

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