Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Clonidine
Drug ID BADD_D00502
Description Clonidine is an imidazole derivate that acts as an agonist of alpha-2 adrenoceptors.[A180559] This activity is useful for the treatment of hypertension, severe pain, and ADHD.[L7237,L7240,L7243,L7246] Clonidine was granted FDA approval on 3 September 1974.[L7237]
Indications and Usage Clonidine tablets and transdermal systems are indicated for the treatment of hypertension alone or in combination with other medications.[L7237,L7240] A clonidine injection is indicated for use with opiates in the treatment of severe cancer pain where opiates alone are insufficient.[L7243] An extended release tablet of clonidine is indicated for the treatment of ADHD either alone or in combination with other medications.[L7246] Clonidine is also used for the diagnosis of pheochromocytoma,[A180565] treatment of nicotine dependance,[A180568] and opiate withdrawal.[A180571]
Marketing Status approved
ATC Code C02AC01; N02CX02; S01EA04
DrugBank ID DB00575
KEGG ID D00281
MeSH ID D003000
PubChem ID 2803
TTD Drug ID D03SKR
NDC Product Code 51862-454; 0597-0033; 69988-0033; 51862-453; 0378-0872; 0591-3510; 0378-0871; 0378-0873; 0597-0032; 0591-3509; 39822-2010; 69238-1426; 50742-247; 0591-3508; 39822-2000; 68134-603; 71511-503; 0597-0031; 51862-455
UNII MN3L5RMN02
Synonyms Clonidine | Klofenil | Clofenil | Chlophazolin | Clonidine Dihydrochloride | Dihydrochloride, Clonidine | Clonidine Hydrochloride | Hydrochloride, Clonidine | Clonidine Monohydrochloride | Monohydrochloride, Clonidine | Clonidine Monohydrobromide | Monohydrobromide, Clonidine | ST-155 | ST 155 | ST155 | Gemiton | Hemiton | Isoglaucon | Klofelin | Clofelin | Clopheline | M-5041T | M 5041T | M5041T | Catapres | Catapresan | Catapressan | Dixarit
Chemical Information
Molecular Formula C9H9Cl2N3
CAS Registry Number 4205-90-7
SMILES C1CN=C(N1)NC2=C(C=CC=C2Cl)Cl
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Lung consolidation22.01.02.0100.000068%Not Available
Malaise08.01.01.003--
Meningitis17.06.03.001; 11.01.03.001--
Metabolic acidosis14.01.01.0030.000114%Not Available
Migraine24.03.05.003; 17.14.02.001--Not Available
Miosis17.02.11.002; 06.05.03.0030.000159%Not Available
Muscle spasms15.05.03.004--
Myalgia15.05.02.001--
Myocardial infarction24.04.04.009; 02.02.02.0070.000068%
Nasal congestion22.04.04.001--
Nasal dryness22.04.03.002--Not Available
Nasopharyngitis22.07.03.002; 11.01.13.002--Not Available
Nausea07.01.07.001--
Neoplasm malignant16.16.01.001--Not Available
Nervous system disorder17.02.10.001--Not Available
Nervousness19.06.02.003--Not Available
Nightmare19.02.03.003--Not Available
Nocturia20.02.03.001--Not Available
Nodal arrhythmia02.03.03.020--Not Available
Oedema14.05.06.010; 08.01.07.006--Not Available
Orthostatic hypotension24.06.03.004; 17.05.01.020--Not Available
Otitis media acute11.01.05.005; 04.05.01.002--Not Available
Pain08.01.08.004--
Pain in extremity15.03.04.010--
Pallor24.03.04.001; 23.03.03.031; 08.01.03.032--Not Available
Palpitations02.11.04.0120.000154%
Papule23.03.03.038--Not Available
Paraesthesia23.03.03.094; 17.02.06.005--
Parotitis11.01.04.001; 07.06.04.001--Not Available
Peripheral coldness23.06.04.008; 24.04.03.006; 08.01.09.0100.000045%Not Available
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ADReCS-Target
Drug Name ADR Term Target
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