| Pharmaceutical Information |
| Drug Name |
Clobetasone butyrate |
| Drug ID |
BADD_D00491 |
| Description |
Clobetasone is a corticosteroid that is often employed topically as a treatment for a variety of conditions such as eczema, psoriasis, various forms of dermatitis, and also for certain ophthalmologic conditions. Topical clobetasone butyrate has shown minimal suppression of the Hypothalamic-pituitary-adrenal axis. |
| Indications and Usage |
In ophthalmology, clobetasone butyrate 0.1% eye drops have been shown to be safe and effective in the treatment of dry eyes in Sjögren's Syndrome. |
| Marketing Status |
Not Available |
| ATC Code |
D07AB01; S01BA09 |
| DrugBank ID |
DB13158
|
| KEGG ID |
D01273
|
| MeSH ID |
C010893
|
| PubChem ID |
71386
|
| TTD Drug ID |
Not Available
|
| NDC Product Code |
52128-153 |
| Synonyms |
clobetasone butyrate | clobetasone 17-butyrate | 21-chloro-11-dehydro-betamethasone-17-butyrate | Eumovate | Emovate | Trimovate |
|
| Chemical Information |
| Molecular Formula |
C26H32ClFO5 |
| CAS Registry Number |
25122-57-0 |
| SMILES |
CCCC(=O)OC1(C(CC2C1(CC(=O)C3(C2CCC4=CC(=O)C=CC43C)F)C)C)C(=O)CCl |
| Chemical Structure |
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| ADR Related Proteins Induced by Drug |
| ADR Term |
Protein Name |
UniProt AC |
TTD Target ID |
PMID |
| Not Available | Not Available | Not Available | Not Available | Not Available |
|
| ADRs Induced by Drug |
|
| ADR Term |
ADReCS ID |
ADR Frequency (FAERS)
|
ADR Severity Grade (FAERS)
|
ADR Severity Grade (CTCAE)
|
| Growth retardation | 15.03.01.006 | - | - | | | Infestation | 23.09.05.001; 11.09.01.001 | - | - | Not Available | | Central obesity | 14.03.02.011 | - | - | Not Available |
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