Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Clemastine fumarate
Drug ID BADD_D00481
Description An ethanolamine-derivative, first generation histamine H1 antagonist used in hay fever, rhinitis, allergic skin conditions, and pruritus. It causes drowsiness.
Indications and Usage For the relief of symptoms associated with allergic rhinitis such as sneezing, rhinorrhea, pruritus and acrimation. Also for the management of mild, uncomplicated allergic skin manifestations of urticaria and angioedema. Used as self-medication for temporary relief of symptoms associated with the common cold.
Marketing Status Prescription; OTC; Discontinued
ATC Code D04AA14; R06AA04
DrugBank ID DB00283
KEGG ID D00666
MeSH ID D002974
PubChem ID 5281069
TTD Drug ID D0C5XC
NDC Product Code 73377-061; 0093-0308; 73308-358; 55152-001; 54838-514
Synonyms Clemastine | Mecloprodin | 2-(2-(1-(4-Chlorophenyl)-1-phenylethoxy)ethyl)-1-methylpyrrolidine | Meclastine | Tavist | Tavegyl | Clemastine Fumarate | HS-592 | HS 592 | HS592
Chemical Information
Molecular Formula C25H30ClNO5
CAS Registry Number 14976-57-9
SMILES CC(C1=CC=CC=C1)(C2=CC=C(C=C2)Cl)OCCC3CCCN3C.C(=CC(=O)O)C(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Nasal congestion22.04.04.001--
Nasal dryness22.04.03.002--Not Available
Nausea07.01.07.001--
Nervousness19.06.02.003--Not Available
Neuritis17.09.03.001--Not Available
Neuropathy peripheral17.09.03.003--Not Available
Palpitations02.01.02.003--
Paraesthesia17.02.06.005--
Photosensitivity reaction23.03.09.003--
Pollakiuria20.02.02.007--
Restlessness19.11.02.002; 17.02.05.021--
Sedation17.02.04.005--Not Available
Seizure17.12.03.001--
Somnolence19.02.05.003; 17.02.04.006--
Tachycardia02.03.02.007--Not Available
Tension19.06.02.005--Not Available
Thrombocytopenia01.08.01.002--Not Available
Tinnitus04.04.01.002; 17.04.07.004--
Tremor17.01.06.002--
Urinary retention20.02.02.011--
Urticaria23.04.02.001; 10.01.06.001--
Vertigo17.02.12.002; 04.04.01.003--
Vision blurred06.02.06.007; 17.17.01.010--
Vomiting07.01.07.003--
Wheezing22.03.01.009--
Decreased appetite14.03.01.005; 08.01.09.028--
Increased bronchial secretion22.02.04.007--Not Available
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