Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Citric acid
Drug ID BADD_D00477
Description A key intermediate in metabolism. It is an acid compound found in citrus fruits. The salts of citric acid (citrates) can be used as anticoagulants due to their calcium chelating ability. Citric acid was one of active ingredients in Phexxi, a non-hormonal contraceptive agent that was approved by the FDA on May 2020.[L14120]
Indications and Usage
Marketing Status Not Available
ATC Code A09AB04
DrugBank ID DB04272
KEGG ID D01222
MeSH ID D019343
PubChem ID 311
TTD Drug ID D02RTS
NDC Product Code 74997-0022; 55549-200; 55549-201
Synonyms Citric Acid | Citric Acid Monohydrate | Uralyt U | Citrate | Citric Acid, Anhydrous | Anhydrous Citric Acid
Chemical Information
Molecular Formula C6H8O7
CAS Registry Number 77-92-9
SMILES C(C(=O)O)C(CC(=O)O)(C(=O)O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Abdominal pain upper07.01.05.003--
Apathy19.04.04.002--Not Available
Asthenia08.01.01.001--Not Available
Blood calcium decreased13.11.01.002--Not Available
Chills15.05.03.016; 08.01.09.001--
Confusional state19.13.01.001; 17.02.03.005--
Diarrhoea07.02.01.001--
Dysarthria17.02.08.001; 19.19.03.001--
Electrocardiogram abnormal13.14.05.001--Not Available
Electrocardiogram QRS complex13.14.05.034--Not Available
Electrocardiogram ST segment13.14.05.035--Not Available
Feeling abnormal08.01.09.014--Not Available
Flat affect19.04.01.004--Not Available
Hyperkalaemia14.05.03.001--
Hypocalcaemia14.04.01.004--
Hypotension24.06.03.002--
Liver disorder09.01.08.001--Not Available
Nausea07.01.07.001--
Paraesthesia17.02.06.005--
Vomiting07.01.07.003--
Citrate toxicity14.11.01.026; 12.03.01.043--Not Available
Poisoning12.03.01.004--Not Available
Gastrointestinal tract irritation07.08.03.008--Not Available
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