Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Citalopram
Drug ID BADD_D00475
Description Citalopram belongs to a class of antidepressant agents known as selective _serotonin-reuptake inhibitors_ (SSRIs) and is widely used to treat the symptoms of depression. Its chemical structure is unrelated to that of other SSRIs or of tricyclic, tetracyclic, or other prescribed antidepressants [FDA label]. Citalopram is also known as _Celexa_, and available in tablet and solution forms [FDA label]. This drug was initially approved by the FDA in 1998 [L5230].
Indications and Usage For the treatment of depression. Off-label indications include: treatment of mild dementia-associated agitation in nonpsychotic patients, smoking cessation, ethanol abuse, obsessive-compulsive disorder (OCD) in children, and diabetic neuropathy [FDA label].
Marketing Status Prescription
ATC Code N06AB04
DrugBank ID DB00215
KEGG ID D07704
MeSH ID D015283
PubChem ID 2771
TTD Drug ID D0Y5DO
NDC Product Code 69097-823; 42806-020; 70518-0561; 43063-385; 43353-112; 70518-2228; 65162-054; 67046-102; 71610-092; 0456-4020; 50090-5170; 69097-824; 68788-7899; 70518-2617; 43063-063; 70934-539; 65162-052; 54458-980; 69097-822; 70518-2553; 0054-0062; 52427-691; 60429-174; 67046-106; 76282-629; 61919-390; 76282-628; 50090-5172; 54458-889; 70518-2601; 70518-2671; 54458-981; 0378-6233; 71335-0541; 60429-173; 71610-412; 63850-3616; 65162-053; 0378-6231; 0456-4010; 42806-021; 76282-206; 68071-3034; 67046-101; 70518-0449; 60429-175; 70934-397; 43353-208; 50090-5175; 63629-6761; 0456-4040; 61919-389; 76282-208; 71610-422; 80425-0093; 76282-207; 0378-6232; 43353-091; 42806-019
Synonyms Citalopram | Cytalopram | Citalopram Hydrobromide | Lu-10-171 | Lu10171 | Seropram | Celexa
Chemical Information
Molecular Formula C20H21FN2O
CAS Registry Number 59729-33-8
SMILES CN(C)CCCC1(C2=C(CO1)C=C(C=C2)C#N)C3=CC=C(C=C3)F
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Poisoning and toxicityCytochrome P450 2D6P10635T57392Not Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Clostridium difficile infection11.02.02.009--Not Available
Holoprosencephaly17.19.01.010; 03.10.03.0070.000043%Not Available
Postpartum depression19.15.01.008; 18.06.03.0020.000083%Not Available
Bradycardia neonatal18.04.07.004; 02.03.02.0190.000916%Not Available
Post viral fatigue syndrome17.06.09.007; 11.05.04.0280.000083%Not Available
Factor V Leiden mutation03.15.01.008; 01.01.02.0190.000167%Not Available
Negative thoughts19.15.02.0120.000208%Not Available
Sopor19.02.04.002; 17.02.04.0210.004249%Not Available
Abdominal compartment syndrome24.04.09.009; 07.11.01.0170.000033%Not Available
Head circumference abnormal13.15.01.0420.000065%Not Available
Antipsychotic drug level above therapeutic13.17.01.0270.000167%Not Available
Communication disorder19.19.01.0080.000125%Not Available
Congenital cardiovascular anomaly24.03.03.011; 03.07.10.001; 02.08.02.0040.000065%Not Available
Disturbance in social behaviour19.05.01.0180.000125%Not Available
Foot deformity15.10.03.0050.000333%Not Available
Hand deformity15.10.03.0070.000083%Not Available
Tricuspid valve disease02.07.05.0040.000167%
Cerebral cyst16.09.05.002; 17.18.05.0020.000083%Not Available
Platelet function test abnormal13.01.04.0060.000167%Not Available
Ultrasound scan abnormal13.18.03.0060.000250%Not Available
Allergy to chemicals10.01.01.0270.000083%Not Available
Antidepressant drug level above therapeutic13.17.01.0250.000167%Not Available
Perforated ulcer08.03.06.0020.000022%Not Available
Single functional kidney20.01.02.0190.000167%Not Available
Atrioventricular septal defect03.07.02.005; 02.04.02.0290.000208%Not Available
Tachyphrenia19.10.03.010; 17.03.03.0070.000333%Not Available
VACTERL syndrome22.04.07.012; 15.03.01.026; 07.11.04.011; 03.02.01.013; 02.08.02.010; 24.03.02.0300.000125%Not Available
Stress cardiomyopathy24.04.04.026; 02.04.01.0120.000167%Not Available
Rectourethral fistula20.07.03.005; 12.02.10.009; 07.11.05.0170.000208%Not Available
Quality of life decreased13.18.01.0130.000250%Not Available
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