Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Citalopram
Drug ID BADD_D00475
Description Citalopram belongs to a class of antidepressant agents known as selective _serotonin-reuptake inhibitors_ (SSRIs) and is widely used to treat the symptoms of depression. Its chemical structure is unrelated to that of other SSRIs or of tricyclic, tetracyclic, or other prescribed antidepressants [FDA label]. Citalopram is also known as _Celexa_, and available in tablet and solution forms [FDA label]. This drug was initially approved by the FDA in 1998 [L5230].
Indications and Usage For the treatment of depression. Off-label indications include: treatment of mild dementia-associated agitation in nonpsychotic patients, smoking cessation, ethanol abuse, obsessive-compulsive disorder (OCD) in children, and diabetic neuropathy [FDA label].
Marketing Status Prescription
ATC Code N06AB04
DrugBank ID DB00215
KEGG ID D07704
MeSH ID D015283
PubChem ID 2771
TTD Drug ID D0Y5DO
NDC Product Code 69097-823; 42806-020; 70518-0561; 43063-385; 43353-112; 70518-2228; 65162-054; 67046-102; 71610-092; 0456-4020; 50090-5170; 69097-824; 68788-7899; 70518-2617; 43063-063; 70934-539; 65162-052; 54458-980; 69097-822; 70518-2553; 0054-0062; 52427-691; 60429-174; 67046-106; 76282-629; 61919-390; 76282-628; 50090-5172; 54458-889; 70518-2601; 70518-2671; 54458-981; 0378-6233; 71335-0541; 60429-173; 71610-412; 63850-3616; 65162-053; 0378-6231; 0456-4010; 42806-021; 76282-206; 68071-3034; 67046-101; 70518-0449; 60429-175; 70934-397; 43353-208; 50090-5175; 63629-6761; 0456-4040; 61919-389; 76282-208; 71610-422; 80425-0093; 76282-207; 0378-6232; 43353-091; 42806-019
Synonyms Citalopram | Cytalopram | Citalopram Hydrobromide | Lu-10-171 | Lu10171 | Seropram | Celexa
Chemical Information
Molecular Formula C20H21FN2O
CAS Registry Number 59729-33-8
SMILES CN(C)CCCC1(C2=C(CO1)C=C(C=C2)C#N)C3=CC=C(C=C3)F
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Poisoning and toxicityCytochrome P450 2D6P10635T57392Not Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Gastritis07.08.02.001--
Gastrooesophageal reflux disease07.02.02.003--
Gastroenteritis11.01.07.004; 07.19.03.001--Not Available
Gastrointestinal disorder07.11.01.001--Not Available
Gastrointestinal haemorrhage24.07.02.009; 07.12.02.001--Not Available
Gastrointestinal pain07.01.05.0050.000083%
Generalised anxiety disorder19.06.01.0040.000125%Not Available
Generalised tonic-clonic seizure17.12.01.0020.001541%Not Available
Gestational diabetes18.02.04.001; 14.06.01.008; 05.06.01.0080.000583%Not Available
Gingival bleeding24.07.02.010; 07.09.07.0010.000250%Not Available
Gingivitis11.01.04.013; 07.09.03.003--
Glaucoma06.03.01.0020.000250%
Glomerular filtration rate decreased13.13.01.009--Not Available
Glossitis07.14.01.001--Not Available
Glossodynia07.14.02.0010.000208%Not Available
Glucose tolerance impaired14.06.02.001; 05.06.02.001--
Glycosylated haemoglobin increased13.02.02.0050.000083%Not Available
Goitre14.11.01.008; 05.02.01.001--Not Available
Granulocytopenia01.02.03.003--Not Available
Gravitational oedema08.01.07.005; 02.05.04.014--Not Available
Gynaecomastia21.05.04.003; 05.05.02.0030.000375%
Haemangioma24.03.06.004; 16.02.01.0020.000083%Not Available
Haemangioma congenital24.03.06.005; 16.02.01.004; 03.07.03.0020.000250%Not Available
Haematemesis07.12.02.002; 24.07.02.0110.000417%Not Available
Haematochezia24.07.02.012; 07.12.02.003--Not Available
Haematoma24.07.01.001--
Haematospermia24.07.03.008; 21.03.03.0030.000167%Not Available
Haematuria24.07.01.047; 20.02.01.006--
Haemoglobin13.01.05.018--Not Available
Haemoglobin decreased13.01.05.003--Not Available
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