Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Cimetidine hydrochloride
Drug ID BADD_D00468
Description A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant therapy.
Indications and Usage For the treatment and the management of acid-reflux disorders (GERD), peptic ulcer disease, heartburn, and acid indigestion.
Marketing Status Prescription; OTC; Discontinued
ATC Code A02BA01
DrugBank ID DB00501
KEGG ID D03503
MeSH ID D002927
PubChem ID 50963
TTD Drug ID D02DPA
NDC Product Code 0121-0649; 50383-966; 0121-1298; 49964-0019
Synonyms Cimetidine | N-Cyano-N'-methyl-N''-(2-(((5-methyl-1H-imidazol-4-yl)methyl)thio)ethyl)guanidine | Biomet | Biomet400 | Cimetidine Hydrochloride | Hydrochloride, Cimetidine | Cimetidine HCl | HCl, Cimetidine | Histodil | SK&F-92334 | SK&F 92334 | SK&F92334 | SKF-92334 | SKF 92334 | SKF92334 | Tagamet | Altramet | Eureceptor
Chemical Information
Molecular Formula C10H17ClN6S
CAS Registry Number 70059-30-2
SMILES CC1=C(N=CN1)CSCCNC(=NC)NC#N.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Haemolytic anaemiaL-lactate dehydrogenase B chainP07195Not AvailableNot Available
Haemolytic anaemiaUDP-glucuronosyltransferase 1A1P22309T93480Not Available
Hyperparathyroidism secondaryParathyroid hormoneP01270T98708Not Available
Hyperparathyroidism secondaryCalcineurin subunit B type 1P63098Not AvailableNot Available
ThrombocytopeniaL-lactate dehydrogenase C chainP07864Not AvailableNot Available
ThrombocytopeniaBifunctional epoxide hydrolase 2P34913T35734Not Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
White blood cell count decreased13.01.06.012--
Tubulointerstitial nephritis20.05.02.002--Not Available
Transaminases increased13.03.01.015--Not Available
Erectile dysfunction21.03.01.007; 19.08.04.001--
Psychotic disorder19.03.01.002--
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