Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Cilostazol
Drug ID BADD_D00466
Description Cilostazol is a quinolinone derivative and antiplatelet agent with vasodilating properties that has been used in the symptomatic treatment of intermittent claudication in patients with peripheral ischaemia. It is marketed under the brand name Pletal by Otsuka Pharmaceutical Co.. Cilostazol works by inhibiting both primary and secondary aggregation and reducing calcium-induced contractions.
Indications and Usage Indicated for the alleviation of symptoms of intermittent claudication (pain in the legs that occurs with walking and disappears with rest).
Marketing Status approved; investigational
ATC Code B01AC23
DrugBank ID DB01166
KEGG ID D01896
MeSH ID D000077407
PubChem ID 2754
TTD Drug ID D03VPC
NDC Product Code 70518-2208; 66039-113; 50268-177; 0054-0028; 46438-0633; 0093-2065; 70436-157; 0054-0044; 63629-8795; 71610-037; 70436-156; 46438-1109; 42291-453; 50090-5329; 60505-2521; 58175-0379; 63415-0034; 60505-2522; 63629-8796; 72189-116; 46438-0632; 50268-176; 70518-2714; 42185-7038; 0093-2064
UNII N7Z035406B
Synonyms Cilostazol | 6-(4-(1-Cyclohexyl-1H-tetrazol-5-yl)butoxy)-3,4-dihydro-2(1H)-quinolinone | OPC 13013 | OPC-13013 | Pletal
Chemical Information
Molecular Formula C20H27N5O2
CAS Registry Number 73963-72-1
SMILES C1CCC(CC1)N2C(=NN=N2)CCCCOC3=CC4=C(C=C3)NC(=O)CC4
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Bone pain15.02.01.001--
Bronchitis11.01.09.001; 22.07.01.001--
Bursitis12.04.03.010; 15.04.01.001--Not Available
Cardiac arrest02.03.04.001--
Cardiac failure02.05.01.0010.000300%
Cardiac failure congestive02.05.01.002--Not Available
Cerebral haemorrhage24.07.04.001; 17.08.01.003--Not Available
Cerebral infarction24.04.06.002; 17.08.01.0040.000300%Not Available
Cerebral ischaemia24.04.06.003; 17.08.01.005--
Cerebrovascular accident17.08.01.007; 24.03.05.001--
Chest pain22.12.02.003; 08.01.08.002; 02.02.02.011--Not Available
Chills15.05.03.016; 08.01.09.001--
Cholelithiasis09.03.01.002--Not Available
Colitis07.08.01.001--
Colon cancer16.13.01.001; 07.21.01.0010.000300%Not Available
Coma17.02.09.0010.000300%Not Available
Condition aggravated08.01.03.0040.000750%Not Available
Conjunctivitis11.01.06.012; 06.04.01.002--
Cough22.02.03.001--
Cystitis20.03.02.002; 11.01.14.001--
Dehydration14.05.05.0010.000450%
Dermatitis23.03.04.002--Not Available
Diabetes mellitus14.06.01.001; 05.06.01.001--Not Available
Diarrhoea07.02.01.0010.001110%
Diplopia17.17.01.005; 06.02.06.002--Not Available
Discomfort08.01.08.003--Not Available
Dizziness24.06.02.007; 17.02.05.003; 02.11.04.0060.000810%
Drug eruption23.03.05.001; 10.01.01.005; 08.01.06.015--Not Available
Drug interaction08.06.03.0010.000600%Not Available
Dry skin23.03.03.001--
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