Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Cilostazol
Drug ID BADD_D00466
Description Cilostazol is a quinolinone derivative and antiplatelet agent with vasodilating properties that has been used in the symptomatic treatment of intermittent claudication in patients with peripheral ischaemia. It is marketed under the brand name Pletal by Otsuka Pharmaceutical Co.. Cilostazol works by inhibiting both primary and secondary aggregation and reducing calcium-induced contractions.
Indications and Usage For the reduction of symptoms of intermittent claudication (pain in the legs that occurs with walking and disappears with rest).
Marketing Status Prescription; Discontinued
ATC Code B01AC23
DrugBank ID DB01166
KEGG ID D01896
MeSH ID D000077407
PubChem ID 2754
TTD Drug ID D03VPC
NDC Product Code 46438-0632; 70518-2208; 72189-116; 66039-113; 0185-0223; 71610-037; 0093-2064; 0093-2065; 60505-2521; 70518-2714; 46438-0633; 50090-5329; 0054-0028; 50268-177; 70436-157; 63629-8796; 70518-2200; 0054-0044; 50268-176; 42291-453; 58175-0379; 70436-156; 63629-8795; 67680-001; 60505-2522; 42185-7038; 63415-0034; 46438-1109
Synonyms Cilostazol | 6-(4-(1-Cyclohexyl-1H-tetrazol-5-yl)butoxy)-3,4-dihydro-2(1H)-quinolinone | OPC 13013 | OPC-13013 | Pletal
Chemical Information
Molecular Formula C20H27N5O2
CAS Registry Number 73963-72-1
SMILES C1CCC(CC1)N2C(=NN=N2)CCCCOC3=CC4=C(C=C3)NC(=O)CC4
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Bone pain15.02.01.001--
Brain herniation17.11.01.002; 12.01.10.0010.000359%Not Available
Bronchitis11.01.09.001; 22.07.01.001--
Bursitis15.04.01.001--Not Available
Cardiac arrest02.03.04.001--
Cardiac failure02.05.01.0010.000359%
Cardiac failure congestive02.05.01.002--Not Available
Cerebral haemorrhage17.08.01.003; 24.07.04.001--Not Available
Cerebral infarction24.04.06.002; 17.08.01.0040.000359%Not Available
Cerebral ischaemia24.04.06.003; 17.08.01.005--
Cerebrovascular accident24.03.05.001; 17.08.01.007--
Chest pain02.02.02.011; 22.02.08.003; 08.01.08.002--Not Available
Chills15.05.03.016; 08.01.09.001--
Cholelithiasis09.03.01.002--Not Available
Colitis07.08.01.001--
Colon cancer16.13.01.001; 07.21.01.0010.001375%Not Available
Conjunctivitis11.01.06.012; 06.04.01.002--
Cough22.02.03.001--
Cystitis20.03.02.002; 11.01.14.001--
Death08.04.01.001--
Dehydration14.05.05.0010.002063%
Dermatitis23.03.04.002--Not Available
Diabetes mellitus14.06.01.001; 05.06.01.001--Not Available
Diabetes mellitus inadequate control14.06.01.004; 05.06.01.0040.001375%Not Available
Diarrhoea07.02.01.0010.003439%
Diplopia06.02.06.002; 17.17.01.005--Not Available
Discomfort08.01.08.003--Not Available
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.0040.002063%
Drug eruption23.03.05.001; 10.01.01.005; 08.01.06.015--Not Available
Dry skin23.03.03.001--
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