Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Cilazapril monohydrate
Drug ID BADD_D00465
Description Cilazapril is an ACE inhibtor class drug used in the treatment of hypertension and heart failure. It belongs to the angiotensin-converting enzyme inhibitors (ACE inhibitors) class of drugs. It is a prodrug that is hydrolyzed after absorption to its main metabolite cilazaprilat. It is branded as Inhibace in Canada and other countries, Vascace and Dynorm in a number of European countries, among many other names. None of these varieties are available in the United States.
Indications and Usage Cilazapril is an ACE inhibtor class drug used in the treatment of hypertension and heart failure.
Marketing Status Not Available
ATC Code C09AA08
DrugBank ID DB01340
KEGG ID D07699
MeSH ID D017315
PubChem ID 56329
TTD Drug ID D04GKO
NDC Product Code Not Available
Synonyms Cilazapril | Cilazapril Monohydrobromide | Cilazapril, Anhydrous | Cilazapril Anhydrous | Cilazapril Monohydrate | Ro 31-2848 | Ro 31 2848 | Ro 312848 | Ro-31-2848 | Ro312848 | Cilazapril Hydrate | Cilazapril, (S*)-Isomer | Inhibace
Chemical Information
Molecular Formula C22H33N3O6
CAS Registry Number 92077-78-6
SMILES CCOC(=O)C(CCC1=CC=CC=C1)NC2CCCN3CCCC(N3C2=O)C(=O)O.O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hypoaesthesia17.02.06.023--Not Available
Hypotension24.06.03.002--
Immune system disorder10.02.01.001--Not Available
Insomnia19.02.01.002; 17.15.03.002--
Laryngeal oedema22.04.02.001; 10.01.05.003; 23.04.01.005--
Leukopenia01.02.02.001--Not Available
Libido decreased21.03.02.005; 19.08.03.001--
Liver function test abnormal13.03.01.013--Not Available
Loss of consciousness17.02.04.004--Not Available
Malaise08.01.01.003--
Menopausal symptoms21.02.02.002--Not Available
Migraine24.03.05.003; 17.14.02.001--Not Available
Muscle spasms15.05.03.004--
Myalgia15.05.02.001--
Myocardial infarction24.04.04.009; 02.02.02.007--
Myocardial ischaemia24.04.04.010; 02.02.02.008--Not Available
Nausea07.01.07.001--
Necrosis24.04.02.006; 08.03.03.001--Not Available
Nephropathy20.05.03.001--Not Available
Nervousness19.06.02.003--Not Available
Neutropenia01.02.03.004--Not Available
Oedema14.05.06.010; 08.01.07.006--Not Available
Orthostatic hypotension17.05.01.020; 24.06.03.004--Not Available
Pain08.01.08.004--
Palpitations02.01.02.003--
Pancreatitis07.18.01.001--
Paraesthesia17.02.06.005--
Pemphigus23.03.01.005; 10.04.02.003--Not Available
Pharyngitis07.05.07.004; 22.07.03.004; 11.01.13.003--
Photophobia17.17.02.006; 06.01.01.004--
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