Pharmaceutical Information |
Drug Name |
Cidofovir dihydrate |
Drug ID |
BADD_D00464 |
Description |
Cidofovir is an injectable antiviral medication employed in the treatment of cytomegalovirus (CMV) retinitis in patients diagnosed with AIDS. It suppresses CMV replication through selective inhibition of viral DNA synthesis.[FDA label] It was manufactured by _Gilead_ and initially approved by the FDA in 1996, but has since been discontinued.[L6223] |
Indications and Usage |
For the treatment of CMV retinitis in patients with acquired immunodeficiency syndrome (AIDS) |
Marketing Status |
Prescription; Discontinued |
ATC Code |
J05AB12 |
DrugBank ID |
DB00369
|
KEGG ID |
D00273
|
MeSH ID |
D000077404
|
PubChem ID |
60933
|
TTD Drug ID |
D04AAW
|
NDC Product Code |
23155-216; 43744-064; 73377-064; 73309-228; 71052-483; 14593-840 |
Synonyms |
Cidofovir | HPMPC | GS 504 | GS-504 | GS504 | Cidofovir, Sodium Salt | Cidofovir Sodium | Cidofovir, (R)-isomer | Cidofovir Anhydrous | 1-(3-Hydroxy-2-phosphonylmethoxypropyl)cytosine | 1-((3-Hydroxy-2-phosphonylmethoxy)propyl)cytosine | Vistide | Cidofovir, (+-)-isomer |
|
Chemical Information |
Molecular Formula |
C8H18N3O8P |
CAS Registry Number |
149394-66-1 |
SMILES |
C1=CN(C(=O)N=C1N)CC(CO)OCP(=O)(O)O.O.O |
Chemical Structure |
|
|
ADR Related Proteins Induced by Drug |
|
ADRs Induced by Drug |
ADR Term |
ADReCS ID |
ADR Frequency (FAERS)
|
ADR Severity Grade (FAERS)
|
ADR Severity Grade (CTCAE)
|
Liver injury | 09.01.07.022; 12.01.02.003 | - | - | Not Available | Anal incontinence | 17.05.01.021; 07.01.06.029 | - | - | |
|
|
|