Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Chloroprocaine
Drug ID BADD_D00438
Description Chloroprocaine hydrochloride is a local anesthetic given by injection during surgical procedures and labor and delivery. Chloroprocaine, like other local anesthetics, blocks the generation and the conduction of nerve impulses, presumably by increasing the threshold for electrical excitation in the nerve, by slowing the propagation of the nerve impulse and by reducing the rate of rise of the action potential.
Indications and Usage For the production of local anesthesia by infiltration and peripheral nerve block. They are not to be used for lumbar or caudal epidural anesthesia.
Marketing Status Prescription; Discontinued
ATC Code N01BA04
DrugBank ID DB01161
KEGG ID D07678
MeSH ID C004616
PubChem ID 8612
TTD Drug ID D07NAJ
NDC Product Code Not Available
Synonyms chloroprocaine | 2-chloroprocaine | chlor-procaine | Nesacaine MPF | chloroprocaine hydrochloride | Nesacaine
Chemical Information
Molecular Formula C13H19ClN2O2
CAS Registry Number 133-16-4
SMILES CCN(CC)CCOC(=O)C1=C(C=C(C=C1)N)Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Acidosis14.01.03.002--
Agitation19.06.02.001; 17.02.05.012--
Angioedema23.04.01.001; 10.01.05.009--Not Available
Anxiety19.06.02.002--
Apnoea22.02.01.001--
Arachnoiditis17.06.01.001; 12.02.04.002--
Back pain15.03.04.005--
Body temperature increased13.15.01.001--Not Available
Bradycardia02.03.02.002--Not Available
Cardiac arrest02.03.04.001--
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Erythema23.03.06.001--Not Available
Headache17.14.01.001--
Hyperhidrosis23.02.03.004; 08.01.03.028--
Hypotension24.06.03.002--
Laryngeal oedema23.04.01.005; 22.04.02.001; 10.01.05.003--
Loss of consciousness17.02.04.004--Not Available
Nausea07.01.07.001--
Pruritus23.03.12.001--
Respiratory arrest22.02.01.009--Not Available
Seizure17.12.03.001--
Shock24.06.02.002--Not Available
Sneezing22.02.05.011--
Somnolence19.02.05.003; 17.02.04.006--
Spinal anaesthesia25.01.03.001--Not Available
Syncope02.01.02.008; 24.06.02.012; 17.02.04.008--
Tachycardia02.03.02.007--Not Available
Tinnitus17.04.07.004; 04.04.01.002--
Tremor17.01.06.002--
Urticaria23.04.02.001; 10.01.06.001--
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