| Pharmaceutical Information |
| Drug Name |
Chlorhexidine diacetate |
| Drug ID |
BADD_D00435 |
| Description |
Chlorhexidine is a broad-spectrum antimicrobial biguanide used as a topical antiseptic and in dental practice for the treatment of inflammatory dental conditions caused by microorganisms.[L11512] It is one of the most common skin and mucous membrane antiseptic agents in use today.[A190417] The molecule itself is a cationic bis-guanide consisting of two 4-chlorophenyl rings and two biguanide groups joined by a central hexamethylene chain.[A190453] Topical chlorhexidine for disinfection, as well as oral rinses for dental use, carries activity against a broad range of pathogens including bacteria, yeasts, and viruses.[L11518,L11512,A190453]
Chlorhexidine was developed in the UK by Imperial Chemical Industries in the early 1950s[A190474] and was introduced to the US in the 1970s.[L11572] |
| Indications and Usage |
For reduction of pocket depth in patients with adult periodontitis, used as an adjunct to scaling and root planing procedures. Also for prevention of dental caries, oropharyngeal decontamination in critically ill patients, hand hygiene in health-care personnel, general skin cleanser, and catheter site preparation and care. |
| Marketing Status |
Not Available |
| ATC Code |
A01AB03; B05CA02; D08AC02; D09AA12; R02AA05; S01AX09; S02AA09; S03AA04 |
| DrugBank ID |
DB00878
|
| KEGG ID |
D07669
|
| MeSH ID |
D002710
|
| PubChem ID |
9562059
|
| TTD Drug ID |
D0V4GY
|
| NDC Product Code |
81615-002; 81615-010; 81615-007; 81615-008; 81615-006 |
| Synonyms |
Chlorhexidine | Chlorhexidine Hydrochloride | Hydrochloride, Chlorhexidine | Tubulicid | Novalsan | Sebidin A | Chlorhexidine Acetate | Acetate, Chlorhexidine | MK-412A | MK 412A | MK412A |
|
| Chemical Information |
| Molecular Formula |
C26H38Cl2N10O4 |
| CAS Registry Number |
56-95-1 |
| SMILES |
CC(=O)O.CC(=O)O.C1=CC(=CC=C1NC(=NC(=NCCCCCCN=C(N)N=C(N)NC2=CC=C(C=C2)Cl)N)N)Cl |
| Chemical Structure |
|
|
| ADR Related Proteins Induced by Drug |
| ADR Term |
Protein Name |
UniProt AC |
TTD Target ID |
PMID |
| Not Available | Not Available | Not Available | Not Available | Not Available |
|
| ADRs Induced by Drug |
|
| ADR Term |
ADReCS ID |
ADR Frequency (FAERS)
|
ADR Severity Grade (FAERS)
|
ADR Severity Grade (CTCAE)
|
| Skin irritation | 23.03.04.009 | - | - | Not Available |
|
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