Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Chloramphenicol
Drug ID BADD_D00430
Description An antibiotic first isolated from cultures of _Streptomyces venequelae_ in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The Extra Pharmacopoeia, 29th ed, p106)
Indications and Usage Used in treatment of cholera, as it destroys the vibrios and decreases the diarrhea. It is effective against tetracycline-resistant vibrios. It is also used in eye drops or ointment to treat bacterial conjunctivitis.
Marketing Status Discontinued
ATC Code D06AX02; D10AF03; G01AA05; J01BA01; S01AA01; S02AA01; S03AA08
DrugBank ID DB00446
KEGG ID D00104
MeSH ID D002701
PubChem ID 5959
TTD Drug ID D0X6IU
NDC Product Code 59929-783; 62991-1031; 53069-0010; 38779-0203; 51927-0214; 71052-687; 72969-011; 66478-0155; 64677-0002; 79572-005
Synonyms Chloramphenicol | Kloramfenikol | Cloranfenicol | Chlornitromycin | Chlorocid | Amphenicol | Amphenicols | Ophthochlor | Syntomycin | Levomycetin | Chloromycetin | Detreomycin
Chemical Information
Molecular Formula C11H12Cl2N2O5
CAS Registry Number 56-75-7
SMILES C1=CC(=CC=C1C(C(CO)NC(=O)C(Cl)Cl)O)[N+](=O)[O-]
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal distension07.01.04.001--
Agranulocytosis01.02.03.001--Not Available
Anaphylactic shock24.06.02.004; 10.01.07.002--Not Available
Angioedema23.04.01.001; 10.01.05.009--Not Available
Aplastic anaemia01.03.03.002--Not Available
Application site irritation12.07.01.003; 08.02.01.003--Not Available
Application site pain12.07.01.004; 08.02.01.004--Not Available
Blister23.03.01.001; 12.01.06.002--Not Available
Body temperature increased13.15.01.001--Not Available
Burning sensation17.02.06.001; 08.01.09.029--Not Available
Circulatory collapse24.06.02.001--Not Available
Confusional state19.13.01.001; 17.02.03.005--
Cyanosis24.03.01.007; 22.02.02.007; 02.01.02.002--
Delirium19.13.02.001--
Dermatitis23.03.04.002--Not Available
Diarrhoea07.02.01.001--
Drug interaction08.06.03.001--Not Available
Endophthalmitis11.01.06.003; 06.04.05.009--
Enterocolitis07.08.03.003--
Eye disorder06.08.03.001--Not Available
Eye irritation06.04.05.003--Not Available
Eye swelling06.08.03.003--Not Available
Feeling abnormal08.01.09.014--Not Available
Gastrointestinal disorder07.11.01.001--Not Available
Glossitis07.14.01.001--Not Available
Grey syndrome neonatal18.04.07.002; 02.05.01.006--Not Available
Headache17.14.01.001--
Hypersensitivity10.01.03.003--
Hypoplastic anaemia01.03.03.006--Not Available
Immune system disorder10.02.01.001--Not Available
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