| Pharmaceutical Information |
| Drug Name |
Chlorambucil |
| Drug ID |
BADD_D00429 |
| Description |
A nitrogen mustard alkylating agent used as antineoplastic agent for the treatment of various malignant and nonmalignant diseases. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed) |
| Indications and Usage |
For treatment of chronic lymphatic (lymphocytic) leukemia, childhood minimal-change nephrotic syndrome, and malignant lymphomas including lymphosarcoma, giant follicular lymphoma, Hodgkin's disease, non-Hodgkin's lymphomas, and Waldenström’s Macroglobulinemia. |
| Marketing Status |
approved |
| ATC Code |
L01AA02 |
| DrugBank ID |
DB00291
|
| KEGG ID |
D00266
|
| MeSH ID |
D002699
|
| PubChem ID |
2708
|
| TTD Drug ID |
D0V8QT
|
| NDC Product Code |
69784-610; 49452-1911; 76055-0025; 80725-610; 50683-0384; 76388-635; 71052-212 |
| UNII |
18D0SL7309
|
| Synonyms |
Chlorambucil | 4-(Bis(2-chloroethyl)amino)benzenebutanoic Acid | N,N-Di-(2-chloroethyl)-p-aminophenylbutyric Acid | Chloraminophene | Chlorbutin | NSC-3088 | NSC 3088 | NSC3088 | Leukeran | Lympholysin | Amboclorin | CB-1348 | CB 1348 | CB1348 |
|
| Chemical Information |
| Molecular Formula |
C14H19Cl2NO2 |
| CAS Registry Number |
305-03-3 |
| SMILES |
C1=CC(=CC=C1CCCC(=O)O)N(CCCl)CCCl |
| Chemical Structure |
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| ADRs Induced by Drug |
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*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
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| ADR Term |
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