Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Cevimeline hydrochloride
Drug ID BADD_D00425
Description Cevimeline is a parasympathomimetic agent that act as an agonist at the muscarinic acetylcholine receptors M1 and M3. It is indicated by the Food and Drug Administration for the treatment of dry mouth associated with Sjögren's syndrome.
Indications and Usage For the treatment of symptoms of dry mouth in patients with Sjögren's Syndrome.
Marketing Status Prescription; Discontinued
ATC Code N07AX03
DrugBank ID DB00185
KEGG ID D00661
MeSH ID C059240
PubChem ID 123603
TTD Drug ID D0Q4CS
NDC Product Code 0054-0334; 46014-1002; 63395-201; 42973-228; 72166-012; 16571-657; 58159-087; 40032-999; 66406-0269; 43386-999
Synonyms cevimeline | 2-methyspiro(1,3-oxathiolane-5,3)quinuclidine | AF 102B, (trans)-isomer | AF-102B | AF 102B | AF102B | Evoxac | FKS 508 | FKS-508 | SNI 2011 | SNI-2011 | AF 102B, (cis-(+))-isomer | cevimeline hydrochloride
Chemical Information
Molecular Formula C10H18ClNOS
CAS Registry Number 107220-28-0
SMILES CC1OC2(CN3CCC2CC3)CS1.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Myocardial infarction24.04.04.009; 02.02.02.007--
Myopia06.02.04.002--Not Available
Nail discolouration23.02.05.001--
Nail disorder23.02.05.002--
Nasal ulcer22.04.03.011--Not Available
Nausea07.01.07.001--
Nephrolithiasis20.04.01.002--
Nephrotic syndrome20.05.01.002--
Neuralgia17.02.07.005--
Neuropathy peripheral17.09.03.003--Not Available
Neurosis19.06.01.001--Not Available
Nightmare19.02.03.003--Not Available
Nocturia20.02.03.001--Not Available
Oedema14.05.06.010; 08.01.07.006--Not Available
Oedema mouth23.04.01.008; 10.01.05.006; 07.05.04.001--Not Available
Oedema peripheral14.05.06.011; 08.01.07.007; 02.05.04.007--
Oesophageal stenosis07.13.02.001--
Oesophagitis07.08.05.001--
Oliguria20.01.03.004--Not Available
Onychomycosis23.09.02.007; 11.03.05.007--Not Available
Orthostatic hypotension24.06.03.004; 17.05.01.020--Not Available
Osteomyelitis15.02.05.001; 11.01.01.001--
Osteonecrosis15.02.04.007; 24.04.05.004--
Osteoporosis14.04.04.002; 15.02.03.002--
Otitis media11.01.05.004; 04.05.01.001--
Ovarian cyst21.11.01.002; 16.04.03.001--Not Available
Ovarian disorder21.11.02.004--Not Available
Pain08.01.08.004--
Pain in extremity15.03.04.010--
Pallor24.03.04.001; 23.03.03.031; 08.01.03.032--Not Available
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