Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Cevimeline
Drug ID BADD_D00424
Description Cevimeline is a parasympathomimetic agent that act as an agonist at the muscarinic acetylcholine receptors M1 and M3. It is indicated by the Food and Drug Administration for the treatment of dry mouth associated with Sjögren's syndrome.
Indications and Usage For the treatment of symptoms of dry mouth in patients with Sjögren's Syndrome.
Marketing Status Prescription; Discontinued
ATC Code N07AX03
DrugBank ID DB00185
KEGG ID D07667
MeSH ID C059240
PubChem ID 2684
TTD Drug ID D0Q4CS
NDC Product Code 63304-479; 64642-011
Synonyms cevimeline | 2-methyspiro(1,3-oxathiolane-5,3)quinuclidine | AF 102B, (trans)-isomer | AF-102B | AF 102B | AF102B | Evoxac | FKS 508 | FKS-508 | SNI 2011 | SNI-2011 | AF 102B, (cis-(+))-isomer | cevimeline hydrochloride
Chemical Information
Molecular Formula C10H17NOS
CAS Registry Number 124620-88-8
SMILES CC1OC2(CN3CCC2CC3)CS1
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Diabetes mellitus14.06.01.001; 05.06.01.001--Not Available
Diarrhoea07.02.01.001--
Diplopia17.17.01.005; 06.02.06.002--Not Available
Discomfort08.01.08.003--Not Available
Diverticulitis11.01.07.003; 07.10.02.001--Not Available
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Dry skin23.03.03.001--
Duodenitis07.08.03.001--Not Available
Dysaesthesia17.02.06.003--
Dysgeusia17.02.07.003; 07.14.03.001--
Dyskinesia17.01.02.006--
Dysmenorrhoea21.01.01.002--
Dyspepsia07.01.02.001--
Dysphagia07.01.06.003--
Dysphonia22.02.05.005; 19.19.03.002; 17.02.08.004--
Dyspnoea02.01.03.002; 22.02.01.004--
Dysuria20.02.02.002--
Ear pain04.03.01.003--
Eczema23.03.04.006--
Electrocardiogram abnormal13.14.05.001--Not Available
Electrocardiogram T wave inversion13.14.05.007--Not Available
Electrolyte imbalance14.05.01.002--Not Available
Endocrine disorder05.09.01.001--Not Available
Endometrial disorder21.07.01.001--Not Available
Enterocolitis07.08.03.003--
Eosinophilia01.02.04.001--
Epididymitis21.09.02.001; 11.01.19.005--Not Available
Epistaxis24.07.01.005; 22.04.03.001--
Eructation07.01.02.003--
Extrasystoles02.03.02.003--Not Available
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