Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Cevimeline
Drug ID BADD_D00424
Description Cevimeline is a parasympathomimetic agent that act as an agonist at the muscarinic acetylcholine receptors M1 and M3. It is indicated by the Food and Drug Administration for the treatment of dry mouth associated with Sjögren's syndrome.
Indications and Usage For the treatment of symptoms of dry mouth in patients with Sjögren's Syndrome.
Marketing Status Prescription; Discontinued
ATC Code N07AX03
DrugBank ID DB00185
KEGG ID D07667
MeSH ID C059240
PubChem ID 2684
TTD Drug ID D0Q4CS
NDC Product Code 63304-479; 64642-011
Synonyms cevimeline | 2-methyspiro(1,3-oxathiolane-5,3)quinuclidine | AF 102B, (trans)-isomer | AF-102B | AF 102B | AF102B | Evoxac | FKS 508 | FKS-508 | SNI 2011 | SNI-2011 | AF 102B, (cis-(+))-isomer | cevimeline hydrochloride
Chemical Information
Molecular Formula C10H17NOS
CAS Registry Number 124620-88-8
SMILES CC1OC2(CN3CCC2CC3)CS1
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Haemorrhage24.07.01.002--Not Available
Rectal tenesmus15.05.03.011; 07.03.03.001--Not Available
Congenital eye disorder06.08.03.011; 03.01.01.002--Not Available
Angiopathy24.03.02.007--Not Available
Blood alkaline phosphatase increased13.04.02.004--
Urine output increased13.13.03.002--Not Available
Hepatic enzyme increased13.03.01.019--Not Available
Hot flush24.03.01.005; 21.02.02.001; 08.01.03.027--
Bacterial infection11.02.01.005--Not Available
Blood electrolytes abnormal13.11.02.002--Not Available
Cardiac disorder02.01.01.003--Not Available
Malnutrition14.03.02.004--Not Available
Decreased appetite08.01.09.028; 14.03.01.005--
Feeling of body temperature change08.01.09.012--Not Available
Erectile dysfunction21.03.01.007; 19.08.04.001--
Ill-defined disorder08.01.03.049--Not Available
Blood disorder01.05.01.004--Not Available
Obstructive airways disorder22.03.01.011--Not Available
Hyperlipidaemia14.08.03.001--
Urine analysis abnormal13.13.02.008--Not Available
Renal impairment20.01.03.010--Not Available
Cystitis noninfective20.03.02.001--
Lichenoid keratosis23.01.01.004--Not Available
Procedural pain12.02.05.007; 08.01.08.009--Not Available
Ulcerative keratitis10.02.01.021; 06.04.02.004--
Post-traumatic pain12.01.08.016; 08.01.08.010--Not Available
Bronchial hyperreactivity22.03.01.016--Not Available
Anorectal discomfort07.03.03.003--Not Available
Toxicity to various agents12.03.01.046--Not Available
Functional gastrointestinal disorder07.11.01.016--Not Available
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