| Pharmaceutical Information |
| Drug Name |
Cetrorelix |
| Drug ID |
BADD_D00419 |
| Description |
Cetrorelix is a man-made hormone that blocks the effects of Gonadotropin Releasing Hormone (GnRH). GnRH controls another hormone that is called luteinizing hormone (LH), which is the hormone that starts ovulation during the menstrual cycle. When undergoing hormone treatment sometimes premature ovulation can occur, leading to eggs that are not ready for fertilization to be released. Cetrorelix does not allow the premature release of these eggs to occur. |
| Indications and Usage |
For the inhibition of premature LH surges in women undergoing controlled ovarian stimulation |
| Marketing Status |
Prescription; Discontinued |
| ATC Code |
H01CC02 |
| DrugBank ID |
DB00050
|
| KEGG ID |
D07665
|
| MeSH ID |
C062876
|
| PubChem ID |
25074887
|
| TTD Drug ID |
D09OLZ
|
| NDC Product Code |
41524-0013; 78848-005 |
| Synonyms |
cetrorelix | N-acetyl-1-(3-(2-naphthyl)alanine)-2-(4-chlorophenylalanine)-3-(3-(3-pyridyl)alanine)-6-citrulline-10-alanine-LHRH | LHRH, N-Ac-1-Nal(2)-2-Phe(pCl)-3-Pal(3)-6-Cit-10-Ala- | LHRH, N-acetyl-1-(3-(2-naphthyl)alanyl)-2-(4-chlorophenylalanyl)-3-(3-(3-pyridyl)alanyl)-6-citrulline-10-alanine- | SB 75 | SB-75 | Cetrotide | cetrorelix acetate | cetrorelix pamoate |
|
| Chemical Information |
| Molecular Formula |
C70H92ClN17O14 |
| CAS Registry Number |
120287-85-6 |
| SMILES |
CC(C)CC(C(=O)NC(CCCN=C(N)N)C(=O)N1CCCC1C(=O)NC(C)C(=O)N)NC(=O)C(CCCNC(=O)N)NC(=O
)C(CC2=CC=C(C=C2)O)NC(=O)C(CO)NC(=O)C(CC3=CN=CC=C3)NC(=O)C(CC4=CC=C(C=C4)Cl)NC(=
O)C(CC5=CC6=CC=CC=C6C=C5)NC(=O)C |
| Chemical Structure |
|
|
| ADR Related Proteins Induced by Drug |
| ADR Term |
Protein Name |
UniProt AC |
TTD Target ID |
PMID |
| Not Available | Not Available | Not Available | Not Available | Not Available |
|
| ADRs Induced by Drug |
|
| ADR Term |
ADReCS ID |
ADR Frequency (FAERS)
|
ADR Severity Grade (FAERS)
|
ADR Severity Grade (CTCAE)
|
| Trisomy 18 | 19.21.06.004; 17.03.07.004; 03.12.01.002; 02.08.01.003 | - | - | Not Available | | Hot flush | 21.02.02.001; 08.01.03.027; 24.03.01.005 | - | - | |
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