Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Celecoxib
Drug ID BADD_D00410
Description Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, is a nonsteroidal anti-inflammatory drug (NSAID) which is known for its decreased risk of causing gastrointestinal bleeding compared to other NSAIDS.[A181544] It is used to manage symptoms of various types of arthritis pain and in familial adenomatous polyposis (FAP) to reduce precancerous polyps in the colon.[A181532] It is marketed by Pfizer under the brand name Celebrex, and was initially granted FDA approval in 1998.[L7604] Interestingly, selective COX-2 inhibitors (especially celecoxib), have been evaluated as potential cancer chemopreventive and therapeutic drugs in clinical trials for a variety of malignancies.[A34124]
Indications and Usage For relief and management of osteoarthritis (OA), rheumatoid arthritis (RA), juvenile rheumatoid arthritis (JRA), ankylosing spondylitis, acute pain, primary dysmenorrhea and oral adjunct to usual care for patients with familial adenomatous polyposis
Marketing Status Prescription
ATC Code L01XX33; M01AH01
DrugBank ID DB00482
KEGG ID D00567
MeSH ID D000068579
PubChem ID 2662
TTD Drug ID D03RTS
NDC Product Code 70247-006; 42806-720; 43063-967; 72567-001; 16714-731; 59385-055; 67296-1600; 51079-199; 65162-819; 50436-0144; 46708-268; 68788-7735; 80425-0167; 65862-793; 13668-307; 69097-422; 80425-0096; 12598-9531; 69097-423; 12598-9516; 55111-898; 67296-1399; 71335-0868; 60429-460; 71610-283; 57582-032; 61919-360; 29300-373; 68180-398; 0591-3984; 70934-220; 0591-3983; 55289-451; 42571-142; 59762-1518; 51655-253; 68180-399; 62332-140; 60687-436; 57582-213; 68788-7286; 64552-4032; 53104-7533; 42806-722; 76420-009; 71209-056; 70518-1346; 65977-0052; 72189-123; 70934-213; 62704-0046; 59746-563; 77771-157; 0378-7150; 0025-1515; 71205-027; 42571-143; 70518-2748; 80425-0040; 75834-236; 65862-908; 71209-054; 63187-301; 42571-144; 63629-8156; 51927-5063; 55700-613; 13668-441; 53002-1338; 0025-1520; 50090-5178; 69367-302; 60687-447; 75834-237; 55154-7646; 50090-3183; 59762-1515; 0093-7165; 80425-0142; 43063-669; 42806-721; 62332-143; 55154-7645; 0591-3985; 68788-7264; 60505-3847; 60505-3849; 0378-7160; 55700-607; 70518-3204; 60505-3848; 71335-0936; 59762-1516; 69097-420; 0093-7170; 45865-970; 63187-633; 70934-469; 61919-837; 51079-215; 69117-0020; 65862-909; 0615-8338; 50228-156; 75834-239; 68981-025; 68180-396; 68071-4476; 69680-135; 69367-301; 65162-820; 0904-6503; 0378-7170; 52048-1995; 29300-157; 16714-734; 50268-168; 77771-156; 33342-158; 77777-115; 50228-159; 0378-7165; 70247-009; 70247-007; 69117-0021; 50090-5638; 42571-145; 69117-0022; 0093-7166; 70934-026; 51552-1461; 80425-0038; 60760-823; 43063-825; 57582-212; 72969-008; 71209-055; 53002-2338; 13668-310; 42708-016; 71205-020; 80425-0039; 67296-1608; 59746-561; 71610-584; 77771-159; 47621-024; 63187-643; 71335-0292; 0025-1530; 65162-818; 77771-158; 65862-910; 80425-0037; 67296-1345; 75834-238; 63187-562; 71335-2019; 71205-439; 71205-055; 65427-002; 60429-462; 13668-442; 62332-141; 62512-0018; 29300-158; 33342-156; 0025-1525; 68071-4392; 58159-067; 46708-267; 72241-025; 60429-461; 46708-270; 68071-4642; 70518-3292; 59762-1517; 65691-0048; 55289-475; 0904-6502; 50228-157; 57582-214; 61919-043; 69097-421; 71335-1804; 72241-023; 62332-142; 43353-257; 60760-824; 63187-079; 29300-374; 16714-733; 0591-3982; 50228-158; 43744-071; 50090-4789; 71209-057; 46708-838; 33342-155; 16714-732; 59746-564; 49706-1880; 63629-3021; 50268-169; 45865-943; 65162-817; 66651-919; 69117-0023; 72761-022; 71335-1066; 68180-395; 68724-1004; 68071-2626; 70518-2922; 65015-882; 57582-211; 33342-157; 72241-022; 45865-840; 46708-269; 65862-907; 42806-723; 59746-562; 60760-209; 0093-7306; 54245-3392; 70247-008; 61919-682; 60429-459; 72241-024
Synonyms Celecoxib | 4-(5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide | Celebrex | SC 58635 | SC-58635 | SC58635
Chemical Information
Molecular Formula C17H14F3N3O2S
CAS Registry Number 169590-42-5
SMILES CC1=CC=C(C=C1)C2=CC(=NN2C3=CC=C(C=C3)S(=O)(=O)N)C(F)(F)F
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Cardiovascular disorder24.03.02.009; 02.01.01.0010.000629%Not Available
Carotid artery stenosis24.04.06.001; 17.08.02.0010.000230%Not Available
Carpal tunnel syndrome17.09.02.0010.000230%Not Available
Cataract06.06.01.001--
Cellulitis23.09.01.001; 11.02.01.001--Not Available
Cerebral haemorrhage24.07.04.001; 17.08.01.003--Not Available
Cerebral infarction24.04.06.002; 17.08.01.004--Not Available
Cerebrovascular accident24.03.05.001; 17.08.01.007--
Cerebrovascular disorder24.03.05.002; 17.08.02.0020.000060%Not Available
Chest discomfort22.02.08.001; 08.01.08.019; 02.02.02.0090.002872%Not Available
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.0110.004480%Not Available
Chills15.05.03.016; 08.01.09.001--
Cholelithiasis09.03.01.002--Not Available
Cholestasis09.01.01.0010.000689%Not Available
Chromatopsia06.02.05.0010.000230%Not Available
Chromaturia20.02.01.0020.000574%
Chronic obstructive pulmonary disease22.03.01.007--Not Available
Coagulopathy01.01.02.0010.000574%Not Available
Colitis07.08.01.001--
Colitis ischaemic24.04.08.012; 07.08.01.0040.000804%Not Available
Colitis ulcerative10.02.01.004; 07.08.01.0050.000574%Not Available
Completed suicide08.04.01.010; 19.12.01.001--Not Available
Concussion17.11.01.004; 12.01.10.0050.000230%Not Available
Confusional state19.13.01.001; 17.02.03.005--
Conjunctival haemorrhage24.07.05.001; 06.07.01.001--Not Available
Conjunctivitis11.01.06.012; 06.04.01.002--
Constipation07.02.02.001--
Coordination abnormal17.02.02.0040.000230%Not Available
Coronary artery disease24.04.04.006; 02.02.01.001--Not Available
Coronary artery occlusion24.04.04.013; 02.02.01.0060.000230%Not Available
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