Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Cefuroxime
Drug ID BADD_D00407
Description Broad-spectrum cephalosporin antibiotic resistant to beta-lactamase. It has been proposed for infections with gram-negative and gram-positive organisms, gonorrhea, and haemophilus.
Indications and Usage For the treatment of many different types of bacterial infections such as bronchitis, sinusitis, tonsillitis, ear infections, skin infections, gonorrhea, and urinary tract infections.
Marketing Status Prescription
ATC Code J01DC02; S01AA27
DrugBank ID DB01112
KEGG ID D00262
MeSH ID D002444
PubChem ID 41375
TTD Drug ID D0Y2IE
NDC Product Code 0143-9567; 0143-9977; 0143-9569; 0143-9979; 0143-9976; 0143-9568
Synonyms Cefuroxime | Cephuroxime | Zinacef | Ketocef
Chemical Information
Molecular Formula C16H16N4O8S
CAS Registry Number 55268-75-2
SMILES CON=C(C1=CC=CO1)C(=O)NC2C3N(C2=O)C(=C(CS3)COC(=O)N)C(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Complex regional pain syndrome12.01.12.004; 17.02.07.0100.000958%Not Available
Oral mucosal exfoliation07.05.05.0110.000958%Not Available
Vulvovaginal mycotic infection21.14.02.004; 11.03.05.004--Not Available
Apparent life threatening event22.11.02.001; 18.04.15.001; 17.02.05.0430.000639%Not Available
Oral disorder07.05.01.0050.000639%Not Available
Brain injury19.07.03.007; 17.11.01.0030.000167%Not Available
Oropharyngeal discomfort22.02.05.027; 07.05.05.0080.000639%Not Available
Kounis syndrome24.04.04.020; 10.01.03.037; 02.02.02.0200.008941%Not Available
Acute kidney injury20.01.03.016--
Macular fibrosis06.09.03.0140.000958%Not Available
Drug-induced liver injury12.03.01.044; 09.01.07.0230.003832%Not Available
Drug reaction with eosinophilia and systemic symptoms23.03.05.005; 10.01.01.0210.003512%Not Available
Candida infection11.03.03.021--
Multiple organ dysfunction syndrome08.01.03.0570.000500%
Alcohol interaction08.06.03.0030.001597%Not Available
Arthritis reactive15.01.01.011; 11.07.01.0130.000639%Not Available
Blood pressure immeasurable13.14.03.0260.000639%Not Available
Gastroenteritis clostridial11.02.02.010; 07.19.03.0160.000639%Not Available
Maternal drugs affecting foetus18.03.03.009; 12.03.03.0060.000958%Not Available
Nosocomial infection11.07.02.0060.000916%Not Available
Small for dates baby18.04.02.0020.000639%Not Available
Urinary tract infection enterococcal20.08.02.007; 11.02.08.0030.000639%Not Available
Vitritis06.04.06.0130.000639%Not Available
Retinal infarction24.04.10.008; 06.10.01.0120.009898%Not Available
Urinary tract infection bacterial20.08.02.006; 11.02.01.0240.000639%Not Available
Clostridium difficile infection11.02.02.0090.004151%Not Available
Retinal neovascularisation06.10.01.013; 05.07.01.006; 24.03.07.015; 14.07.01.0060.000639%Not Available
Retinoschisis06.09.03.0250.001916%Not Available
Stress cardiomyopathy24.04.04.026; 02.04.01.0120.000639%Not Available
Toxic anterior segment syndrome06.04.10.006; 12.02.02.0100.002554%Not Available
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