ADReCS

Pharmaceutical Information

Drug Name	Cefuroxime
Drug ID	BADD_D00407
Description	Broad-spectrum cephalosporin antibiotic resistant to beta-lactamase. It has been proposed for infections with gram-negative and gram-positive organisms, gonorrhea, and haemophilus.
Indications and Usage	For the treatment of many different types of bacterial infections such as bronchitis, sinusitis, tonsillitis, ear infections, skin infections, gonorrhea, and urinary tract infections.
Marketing Status	approved
ATC Code	J01DC02; S01AA27
DrugBank ID	DB01112
KEGG ID	D00262
MeSH ID	D002444
PubChem ID	41375
TTD Drug ID	D0Y2IE
NDC Product Code	0143-9567; 0143-9569; 0143-9976; 0143-9568; 0143-9977; 0143-9979
UNII	O1R9FJ93ED
Synonyms	Cefuroxime \| Cephuroxime \| Zinacef \| Ketocef

Chemical Information

Molecular Formula	C16H16N4O8S
CAS Registry Number	55268-75-2
SMILES	CON=C(C1=CC=CO1)C(=O)NC2C3N(C2=O)C(=C(CS3)COC(=O)N)C(=O)O
Chemical Structure

ADRs Induced by Drug

*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..

ADR Term	ADReCS ID	ADR Frequency (FAERS)	ADR Severity Grade (FAERS)	ADR Severity Grade (CTCAE)
Musculoskeletal discomfort	15.03.04.001	-	-	Not Available
Secretion discharge	08.01.03.019	-	-	Not Available
Type IV hypersensitivity reaction	10.01.03.022	0.000572%		Not Available
Anterior chamber cell	06.04.10.001	0.000143%		Not Available
Nodule	08.03.05.002	0.000215%		Not Available
Skin candida	23.11.03.009; 11.03.03.010	-	-	Not Available
Dental discomfort	07.09.06.002	0.000143%		Not Available
Anterior chamber inflammation	06.04.10.002	0.001645%		Not Available
Skin burning sensation	23.03.03.021; 17.02.06.009	0.000630%		Not Available
Haemorrhage	24.07.01.002	-	-	Not Available
Vulvovaginal pruritus	23.03.12.009; 21.08.02.004	-	-	Not Available
Paraesthesia oral	17.02.06.008; 07.05.05.035	0.000143%		Not Available
Anterior chamber pigmentation	06.06.07.001	0.001216%		Not Available
Cystoid macular oedema	06.04.06.010; 12.02.02.005	0.000930%		Not Available
Retroperitoneal haematoma	24.07.01.060; 07.07.02.005	0.000143%		Not Available
Angiopathy	24.03.02.007	-	-	Not Available
Blood alkaline phosphatase increased	13.04.02.004	-	-
Drug resistance	08.06.01.005	0.000787%		Not Available
Hepatic enzyme increased	13.03.04.028	-	-	Not Available
Appetite disorder	19.09.01.002; 14.03.01.004	0.000143%		Not Available
Coombs test positive	13.01.01.002	-	-	Not Available
Ocular toxicity	12.03.01.031; 06.11.01.006	0.002947%		Not Available
Infestation	23.11.01.002; 11.09.01.001	-	-	Not Available
Limb discomfort	15.03.04.014	0.000486%		Not Available
Partial seizures	17.12.03.010	0.000215%		Not Available
Decreased appetite	14.03.01.005; 08.01.09.028	-	-
Sensation of foreign body	08.01.09.002	0.000143%		Not Available
Blood disorder	01.05.01.004	-	-	Not Available
Psychotic disorder	19.03.01.002	0.000215%
Hepatobiliary disease	09.01.08.003	-	-	Not Available

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