Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Cefoperazone
Drug ID BADD_D00389
Description Cefoperazone is a semisynthetic broad-spectrum cephalosporin proposed to be effective against Pseudomonas infections. It is a third-generation antiobiotic agent and it is used in the treatment of various bacterial infections caused by susceptible organisms in the body, including respiratory tract infections, peritonitis, skin infections, endometritis, and bacterial septicemia. While its clinical use has been discontinued in the U.S., cefoperazone is available in several European countries most commonly under the product name, Sulperazon.
Indications and Usage For the treatment of bacterial infections caused by susceptible microorganisms.
Marketing Status Discontinued
ATC Code J01DD12
DrugBank ID DB01329
KEGG ID D07645
MeSH ID D002438
PubChem ID 44187
TTD Drug ID D0C2YB
NDC Product Code Not Available
Synonyms Cefoperazone | Cefoperazon | Cefoperazone Sodium | Sodium, Cefoperazone | Cefoperazone Sodium Salt | Salt, Cefoperazone Sodium | Sodium Salt, Cefoperazone | T1551 | T-1551 | T 1551 | Cefobid | Céfobis
Chemical Information
Molecular Formula C25H27N9O8S2
CAS Registry Number 62893-19-0
SMILES CCN1CCN(C(=O)C1=O)C(=O)NC(C2=CC=C(C=C2)O)C(=O)NC3C4N(C3=O)C(=C(CS4)CSC5=NN=NN5C) C(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Blood creatinine13.13.01.020--Not Available
Blood urea increased13.13.01.006--Not Available
Diarrhoea07.02.01.001--
Eosinophilia01.02.04.001--
Haemoglobin decreased13.01.05.003--Not Available
Nausea07.01.07.001--
Neutropenia01.02.03.004--Not Available
Neutrophil count decreased13.01.06.010--
Pain08.01.08.004--
Pseudomembranous colitis11.02.02.002; 07.19.01.003--Not Available
Pyrexia08.05.02.003--
Skin reaction23.03.03.013; 10.01.03.019--Not Available
Vomiting07.01.07.003--
Haematocrit abnormal13.01.05.012--Not Available
Infusion site phlebitis24.05.03.002; 12.07.05.004; 08.02.05.003--Not Available
Hepatic enzyme increased13.03.01.019--Not Available
Coombs test13.01.01.005--Not Available
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