Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Cefixime
Drug ID BADD_D00388
Description Cefixime, an antibiotic, is a third-generation cephalosporin like ceftriaxone and cefotaxime. Cefixime is highly stable in the presence of beta-lactamase enzymes. As a result, many organisms resistant to penicillins and some cephalosporins due to the presence of beta-lactamases, may be susceptible to cefixime. The antibacterial effect of cefixime results from inhibition of mucopeptide synthesis in the bacterial cell wall.
Indications and Usage For use in the treatment of the following infections when caused by susceptible strains of the designated microorganisms: (1) uncomplicated urinary tract infections caused by Escherichia coli and Proteus mirabilis, (2) otitis media caused by Haemophilus influenzae (beta-lactamase positive and negative strains), Moraxella catarrhalis (most of which are beta-lactamase positive), and S. pyogenes, (3) pharyngitis and tonsillitis caused by S. pyogenes, (4) acute bronchitis and acute exacerbations of chronic bronchitis caused by Streptococcus pneumoniae and Haemophilus influenzae (beta-lactamase positive and negative strains), and (5) uncomplicated gonorrhea (cervical/urethral) caused by Neisseria gonorrhoeae (penicillinase- and non-penicillinase-producing strains).
Marketing Status approved; investigational
ATC Code J01DD08
DrugBank ID DB00671
KEGG ID D00258; D07640
MeSH ID D020682
PubChem ID 5362065
TTD Drug ID D06OVY
NDC Product Code 82608-007; 67877-584; 68180-423; 83112-584; 27437-201; 27437-203; 27437-208; 62250-663; 62250-668; 68180-405; 65862-791; 27437-205; 27437-207; 16714-767; 27437-206; 70518-3221; 43598-673; 68180-202; 62250-664; 65862-751; 68180-407; 61788-3000; 16714-766; 43598-674; 65862-752; 70518-2749
UNII 97I1C92E55
Synonyms Cefixime | Suprax | Cefixime Anhydrous | Cefixime Trihydrate | FK-027 | FK027 | FK 027 | FR-17027 | FR 17027 | FR17027
Chemical Information
Molecular Formula C16H15N5O7S2
CAS Registry Number 79350-37-1
SMILES C=CC1=C(N2C(C(C2=O)NC(=O)C(=NOCC(=O)O)C3=CSC(=N3)N)SC1)C(=O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal distension07.01.04.001--
Abdominal pain07.01.05.0020.001085%
Abdominal pain upper07.01.05.003--
Abnormal faeces07.01.03.001--Not Available
Agranulocytosis01.02.03.0010.000724%Not Available
Alanine aminotransferase increased13.03.04.005--
Anaphylactic reaction24.06.03.006; 10.01.07.001--
Anaphylactic shock24.06.02.004; 10.01.07.0020.000724%Not Available
Anaphylactoid reaction24.06.03.007; 10.01.07.003--Not Available
Angioedema22.04.02.008; 23.04.01.001; 10.01.05.0090.000724%Not Available
Anxiety19.06.02.002--
Aplastic anaemia01.03.03.002--Not Available
Arthralgia15.01.02.001--
Aspartate aminotransferase increased13.03.04.011--
Asthenia08.01.01.0010.000724%Not Available
Blister23.03.01.001; 12.01.06.002--Not Available
Blood bilirubin increased13.03.04.018--
Blood creatinine increased13.13.01.004--
Blood lactate dehydrogenase increased13.04.02.002--
Blood urea increased13.13.01.006--Not Available
Body temperature increased13.15.01.001--Not Available
Cachexia14.03.02.001; 08.01.01.009; 16.32.03.0110.001085%Not Available
Chills15.05.03.016; 08.01.09.0010.001085%
Cholestasis09.01.01.001--Not Available
Colitis07.08.01.001--
Condition aggravated08.01.03.0040.001809%Not Available
Coombs direct test positive13.01.01.001--Not Available
Cough22.02.03.0010.000724%
Dehydration14.05.05.001--
Dermatitis23.03.04.002--Not Available
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