Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Cefazolin sodium
Drug ID BADD_D00383
Description A semisynthetic cephalosporin analog with broad-spectrum antibiotic action due to inhibition of bacterial cell wall synthesis. It attains high serum levels and is excreted quickly via the urine.
Indications and Usage Mainly used to treat bacterial infections of the skin. It can also be used to treat moderately severe bacterial infections involving the lung, bone, joint, stomach, blood, heart valve, and urinary tract. It is clinically effective against infections caused by staphylococci and streptococci species of Gram positive bacteria. May be used for surgical prophylaxis; if required metronidazole may be added to cover B. fragilis.
Marketing Status Prescription; Discontinued
ATC Code J01DB04
DrugBank ID DB01327
KEGG ID D00905
MeSH ID D002437
PubChem ID 23675322
TTD Drug ID D09KDN
NDC Product Code 25021-100; 25021-102; 25021-101; 63323-237; 0264-3103; 0338-3508; 66288-1300; 0264-3105; 63323-236; 66288-1100; 0338-3503; 63323-238
Synonyms Cefazolin | Cephazolin | Cefamedin | Cefamezine | Cephamezine | Gramaxin | Kefzol | Totacef | Ancef | Cefazolin Sodium | Sodium, Cefazolin | Sodium Cephazolin | Cephazolin, Sodium | Cephazolin Sodium | Sodium, Cephazolin
Chemical Information
Molecular Formula C14H13N8NaO4S3
CAS Registry Number 27164-46-1
SMILES CC1=NN=C(S1)SCC2=C(N3C(C(C3=O)NC(=O)CN4C=NN=N4)SC2)C(=O)[O-].[Na+]
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain upper07.01.05.003--
Alanine aminotransferase increased13.03.01.003--
Anaphylactic reaction10.01.07.001; 24.06.03.006--
Aspartate aminotransferase increased13.03.01.006--
Blood urea increased13.13.01.006--Not Available
Diarrhoea07.02.01.001--
Eosinophilia01.02.04.001--
Leukopenia01.02.02.001--Not Available
Nausea07.01.07.001--
Neutropenia01.02.03.004--Not Available
Oral candidiasis11.03.03.004; 07.05.07.001--Not Available
Pain08.01.08.004--
Phlebitis24.05.03.001; 12.02.01.002--
Pruritus23.03.12.001--
Pruritus genital23.03.12.008; 21.10.01.002--Not Available
Pseudomembranous colitis11.02.02.002; 07.19.01.003--Not Available
Pyrexia08.05.02.003--
Rash23.03.13.001--Not Available
Stevens-Johnson syndrome23.03.01.007; 12.03.01.014; 11.07.01.005; 10.01.03.020--
Thrombocytopenia01.08.01.002--Not Available
Thrombocytosis01.08.02.001--Not Available
Vomiting07.01.07.003--
Blood alkaline phosphatase increased13.04.02.004--
Induration08.01.03.020--Not Available
Decreased appetite14.03.01.005; 08.01.09.028--
Anal pruritus07.03.03.002--Not Available
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