Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Cefazolin
Drug ID BADD_D00382
Description A semisynthetic cephalosporin analog with broad-spectrum antibiotic action due to inhibition of bacterial cell wall synthesis. It attains high serum levels and is excreted quickly via the urine.
Indications and Usage Mainly used to treat bacterial infections of the skin. It can also be used to treat moderately severe bacterial infections involving the lung, bone, joint, stomach, blood, heart valve, and urinary tract. It is clinically effective against infections caused by staphylococci and streptococci species of Gram positive bacteria. May be used for surgical prophylaxis; if required metronidazole may be added to cover B. fragilis.
Marketing Status Prescription; Discontinued
ATC Code J01DB04
DrugBank ID DB01327
KEGG ID D02299
MeSH ID D002437
PubChem ID 33255
NDC Product Code 71872-7141; 0781-3450; 50090-4256; 44567-706; 72572-055; 71872-7027; 0143-9665; 0404-9833; 67184-1001; 0143-9924; 0143-9983; 60505-6142; 52584-923; 0143-9261; 44567-707; 0781-3452; 0781-3451; 70518-3047; 67184-0560; 17337-0300; 0143-9262; 0404-9834; 52584-087; 0143-9923; 60505-6231; 52584-924; 44567-120; 0404-9835; 72572-056; 0409-2585; 60505-6143; 44567-708
Synonyms Cefazolin | Cephazolin | Cefamedin | Cefamezine | Cephamezine | Gramaxin | Kefzol | Totacef | Ancef | Cefazolin Sodium | Sodium, Cefazolin | Sodium Cephazolin | Cephazolin, Sodium | Cephazolin Sodium | Sodium, Cephazolin
Chemical Information
Molecular Formula C14H14N8O4S3
CAS Registry Number 25953-19-9
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.0020.000532%
Abdominal pain upper07.01.05.003--
Acute hepatic failure09.01.03.0010.000083%Not Available
Acute myocardial infarction02.02.02.001; Available
Agranulocytosis01.02.03.001--Not Available
Alanine aminotransferase increased13.03.01.003--
Altered state of consciousness19.07.01.003; Available
Anaphylactic reaction24.06.03.006;
Anaphylactic shock24.06.02.004; Available
Angioedema23.04.01.001; Available
Aplastic anaemia01.03.03.002--Not Available
Arrhythmia02.03.02.0010.000213%Not Available
Aspartate aminotransferase increased13.03.01.006--
Asthenia08.01.01.001--Not Available
Blood alkaline phosphatase13.04.02.010--Not Available
Blood bilirubin increased13.03.01.008--
Blood creatinine increased13.13.01.0040.000319%
Blood lactate dehydrogenase increased13.04.02.002--
Blood pressure decreased13.14.03.0020.000213%Not Available
Blood urea increased13.13.01.006--Not Available
Body temperature increased13.15.01.001--Not Available
Bradycardia02.03.02.0020.000426%Not Available
C-reactive protein increased13.09.01.0070.000213%Not Available
Cardiac arrest02.03.04.0010.000139%
Cardiac failure congestive02.05.01.002--Not Available
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