Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Caspofungin acetate
Drug ID BADD_D00377
Description Caspofungin (brand name Cancidas worldwide) is an antifungal drug and the first member of a new drug class called the echinocandins, as coined by Merck & Co., Inc. It is typically administered intravenously. It shows activity against infections with Aspergillus and Candida, and works by inhibiting β(1,3)-D-Glucan of the fungal cell wall.
Indications and Usage For the treatment of esophageal candidiasis and invasive aspergillosis in patients who are refractory to or intolerant of other therapies.
Marketing Status Prescription
ATC Code J02AX04
DrugBank ID DB00520
KEGG ID D02501
MeSH ID D000077336
PubChem ID 6850808
TTD Drug ID D00ZCN
NDC Product Code 63323-356; 0006-3822; 69097-366; 14474-037; 62227-022; 70860-107; 68083-159; 72611-702; 0781-3423; 68083-158; 69806-0092; 72843-533; 69097-365; 69766-064; 70860-106; 0006-3823; 63323-358; 72266-106; 57884-0030; 72843-434; 72266-107; 0781-3421; 52076-6230; 72611-700
Synonyms Caspofungin | Cancidas | MK 0991 | MK-0991 | MK0991 | Caspofungin MSD | L 743,872 | L-743,872 | L743,872 | L-743872 | L743872 | L 743872 | Caspofungin Acetate
Chemical Information
Molecular Formula C56H96N10O19
CAS Registry Number 179463-17-3
SMILES CCC(C)CC(C)CCCCCCCCC(=O)NC1CC(C(NC(=O)C2C(CCN2C(=O)C(NC(=O)C(NC(=O)C3CC(CN3C(=O) C(NC1=O)C(C)O)O)C(C(C4=CC=C(C=C4)O)O)O)C(CCN)O)O)NCCN)O.CC(=O)O.CC(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal distension07.01.04.001--
Abdominal pain07.01.05.002--
Abdominal pain upper07.01.05.003--
Alanine aminotransferase increased13.03.01.003--
Anaemia01.03.02.001--
Anxiety19.06.02.002--
Arrhythmia02.03.02.001--Not Available
Arthralgia15.01.02.001--
Aspartate aminotransferase increased13.03.01.006--
Asthenia08.01.01.001--Not Available
Atrial fibrillation02.03.03.002--
Back pain15.03.04.005--
Bacteraemia11.01.11.001--
Bilirubin conjugated increased13.03.01.007--Not Available
Blood albumin decreased13.09.01.001--Not Available
Blood bilirubin increased13.03.01.008--
Blood creatinine increased13.13.01.004--
Blood glucose increased13.02.02.002--Not Available
Blood magnesium decreased13.11.01.008--Not Available
Blood potassium decreased13.11.01.010--Not Available
Blood urea increased13.13.01.006--Not Available
Bradycardia02.03.02.002--Not Available
Cardiac arrest02.03.04.001--
Chills15.05.03.016; 08.01.09.001--
Coagulopathy01.01.02.001--Not Available
Confusional state17.02.03.005; 19.13.01.001--
Constipation07.02.02.001--
Cough22.02.03.001--
Decubitus ulcer23.03.11.006--Not Available
Depression19.15.01.001--
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