Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Caspofungin
Drug ID BADD_D00376
Description Caspofungin (brand name Cancidas worldwide) is an antifungal drug and the first member of a new drug class called the echinocandins, as coined by Merck & Co., Inc. It is typically administered intravenously. It shows activity against infections with Aspergillus and Candida, and works by inhibiting β(1,3)-D-Glucan of the fungal cell wall.
Indications and Usage For the treatment of esophageal candidiasis and invasive aspergillosis in patients who are refractory to or intolerant of other therapies.
Marketing Status Prescription
ATC Code J02AX04
DrugBank ID DB00520
KEGG ID D07626
MeSH ID D000077336
PubChem ID 2826718
TTD Drug ID D00ZCN
NDC Product Code Not Available
Synonyms Caspofungin | Cancidas | MK 0991 | MK-0991 | MK0991 | Caspofungin MSD | L 743,872 | L-743,872 | L743,872 | L-743872 | L743872 | L 743872 | Caspofungin Acetate
Chemical Information
Molecular Formula C52H88N10O15
CAS Registry Number 162808-62-0
SMILES CCC(C)CC(C)CCCCCCCCC(=O)NC1CC(C(NC(=O)C2C(CCN2C(=O)C(NC(=O)C(NC(=O)C3CC(CN3C(=O) C(NC1=O)C(C)O)O)C(C(C4=CC=C(C=C4)O)O)O)C(CCN)O)O)NCCN)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Device related infection11.01.08.018; 08.07.01.005--
Infusion site extravasation08.02.05.007; 12.07.05.008--
Breath sounds abnormal13.15.01.008--Not Available
Infusion site irritation12.07.05.011; 08.02.05.010--Not Available
Infusion site urticaria08.02.05.021; 23.04.02.010; 12.07.05.021; 10.01.06.010--Not Available
Haematological malignancy16.21.01.002; 01.13.01.003--Not Available
Treatment failure08.06.01.0170.000368%Not Available
Acute kidney injury20.01.03.0160.001057%
Drug-induced liver injury12.03.01.044; 09.01.07.0230.000705%Not Available
Drug reaction with eosinophilia and systemic symptoms23.03.05.005; 10.01.01.0210.001762%Not Available
Candida infection11.03.03.0210.000705%
Aspergillus infection11.03.01.0040.000184%Not Available
Multiple organ dysfunction syndrome08.01.03.0570.000460%
Dermatitis exfoliative generalised10.01.01.029; 23.03.07.0020.000705%Not Available
Trichosporon infection11.03.05.0310.000705%Not Available
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