Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Carvedilol phosphate
Drug ID BADD_D00375
Description Carvedilol is a racemic mixture where the S(-) enantiomer is a beta adrenoceptor blocker and the R(+) enantiomer is both a beta and alpha-1 adrenoceptor blocker.[L7889,L7892] It is currently used to treat heart failure, left ventricular dysfunction, and hypertension.[L7889,L7892] The dual action of carvedilol is advantageous in combination therapies as moderate doses of 2 drugs have a decreased incidence of adverse effects compared to high dose monotherapy in the treatment of moderate hypertension.[A182306] Carvedilol was granted FDA approval on 14 September 1995.[L7889]
Indications and Usage For the treatment of mild or moderate (NYHA class II or III) heart failure of ischemic or cardiomyopathic origin.
Marketing Status Prescription; Discontinued
ATC Code C07AG02
DrugBank ID DB01136
KEGG ID D03415
MeSH ID D000077261
PubChem ID 9827459
NDC Product Code 69784-713; 72761-003; 60505-4715; 51407-052; 12658-0590; 0007-3371; 60505-4714; 61187-004; 0007-3387; 60505-3678; 60505-4713; 57664-665; 0007-3370; 65015-884; 57664-666; 60505-3679; 16714-229; 60505-3680; 16714-227; 0007-3385; 0007-3388; 69784-716; 36974-0067; 63629-8794; 51407-053; 16714-228; 69784-714; 51407-051; 60505-4716; 0007-3383; 60505-3681; 53873-061; 63415-0127; 16714-230; 51407-050; 53873-060; 53873-062; 53873-063; 69784-715; 0007-3372; 57664-663; 0007-3373; 57664-664
Synonyms Carvedilol | Carvedilol Hydrochloride | Dilatrend | Querto | Eucardic | Carvedilol, (S)-isomer | Kredex | BM 14190 | BM-14190 | BM14190 | Carvedilol, (R)-isomer | Carvedilol, (+)-isomer | Carvedilol, (+) | Carvedilol, (+-)-isomer | Carvedilol, (-)-isomer | Carvedilol, (-) | Carvedilol, 14C-labeled | 14C-labeled Carvedilol | Carvedilol, 14C labeled | Coropres | Coreg
Chemical Information
Molecular Formula C24H29N2O8P
CAS Registry Number 374779-45-0
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Adverse drug reactionCytochrome P450 2D6P10635T57392Not Available
Atrioventricular block first degreeCytochrome P450 2D6P10635T57392Not Available
Heart rate decreasedCytochrome P450 2D6P10635T57392Not Available
Left ventricular dysfunctionATP-dependent translocase ABCB1P08183T25258Not Available
Vascular disordersProto-oncogene tyrosine-protein kinase SrcP12931T85943Not Available
Vascular disordersVascular endothelial growth factor receptor 2P35968T80975Not Available
Vascular disordersMitogen-activated protein kinase 1P28482T58970Not Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Alanine aminotransferase increased13.03.01.003--
Anaphylactic reaction24.06.03.006;
Anaphylactoid reaction10.01.07.003; Available
Angina pectoris24.04.04.002;
Angioedema23.04.01.001; Available
Aplastic anaemia01.03.03.002--Not Available
Aspartate aminotransferase increased13.03.01.006--
Asthenia08.01.01.001--Not Available
Asthma22.03.01.002; Available
Atrioventricular block02.03.01.002--Not Available
Atrioventricular block complete02.03.01.003--
Blood creatinine increased13.13.01.004--
Blood urea increased13.13.01.006--Not Available
Bradycardia02.03.02.002--Not Available
Bundle branch block02.03.01.009--Not Available
Cardiac failure02.05.01.001--
Cerebrovascular disorder24.03.05.002; Available
Dermatitis exfoliative23.03.07.001;
Diabetes mellitus14.06.01.001; Available
Disturbance in attention19.21.02.002;
Dry mouth07.06.01.002--
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