Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Carvedilol
Drug ID BADD_D00374
Description Carvedilol is a racemic mixture where the S(-) enantiomer is a beta adrenoceptor blocker and the R(+) enantiomer is both a beta and alpha-1 adrenoceptor blocker.[L7889,L7892] It is currently used to treat heart failure, left ventricular dysfunction, and hypertension.[L7889,L7892] The dual action of carvedilol is advantageous in combination therapies as moderate doses of 2 drugs have a decreased incidence of adverse effects compared to high dose monotherapy in the treatment of moderate hypertension.[A182306] Carvedilol was granted FDA approval on 14 September 1995.[L7889]
Indications and Usage For the treatment of mild or moderate (NYHA class II or III) heart failure of ischemic or cardiomyopathic origin.
Marketing Status Prescription; Discontinued
ATC Code C07AG02
DrugBank ID DB01136
KEGG ID D00255
MeSH ID D000077261
PubChem ID 2585
TTD Drug ID D0W9LX
NDC Product Code 71335-0368; 65862-142; 64220-150; 0615-8390; 50090-1856; 65691-0087; 61919-984; 68462-162; 43353-838; 63187-570; 68462-164; 68001-152; 0781-5222; 68001-154; 65862-145; 43063-125; 63187-409; 60760-234; 71335-1545; 71335-1407; 43353-874; 50090-2175; 71610-067; 68382-092; 68071-4470; 63187-424; 53104-7575; 51079-930; 61919-730; 65862-144; 70934-517; 68788-9789; 65841-617; 68071-3151; 70518-2389; 71335-0034; 70518-1377; 68071-4495; 35356-526; 61919-728; 63629-4070; 0615-8388; 42419-013; 68645-350; 72761-004; 55154-6883; 43353-837; 70934-406; 70518-0582; 0904-6300; 55154-5678; 72888-037; 68462-165; 51407-041; 0615-8387; 50090-1064; 55154-7278; 68071-4956; 70934-759; 70518-0356; 71610-066; 0904-6301; 63187-941; 43063-126; 50090-4898; 51655-397; 0093-7295; 68382-095; 70934-707; 51655-033; 65862-143; 51079-771; 51079-931; 61919-219; 55111-252; 68645-351; 70934-609; 68294-0005; 53002-1572; 60760-494; 76385-113; 50090-1069; 71335-1813; 68788-8151; 65841-618; 68001-151; 55111-255; 51407-039; 71335-2023; 57451-1155; 0904-6302; 0378-3633; 55154-6885; 60760-532; 71335-1533; 68788-7910; 52932-0726; 70934-515; 68071-4600; 68645-496; 47621-064; 0007-4140; 50090-2555; 0615-8018; 0093-7296; 63187-131; 68788-7883; 71335-2033; 68462-163; 71335-0561; 63187-946; 70786-0144; 42708-072; 0615-7946; 60760-235; 43353-832; 68788-7539; 55154-5676; 68071-4980; 76385-111; 50090-4171; 70934-910; 43063-833; 0615-8389; 61919-533; 53002-1574; 68084-854; 71610-132; 68788-7603; 50090-2119; 70518-0426; 68071-3078; 63629-4060; 51407-040; 55111-030; 53002-1573; 0781-5224; 0007-4141; 60760-233; 0904-6303; 76385-110; 70934-753; 68001-153; 60760-376; 68382-094; 70518-1826; 71335-2026; 70934-686; 0781-5221; 71335-1128; 0093-0051; 63187-447; 51407-042; 65862-369; 71335-1623; 53002-1556; 76385-112; 55111-254; 70934-211; 71610-062; 51079-932; 68071-2230; 50090-5115; 0378-3634; 50090-2066; 68382-093; 55154-6884; 68071-4974; 71335-1457; 68071-2633; 55700-819; 72888-034; 0615-7944; 71610-063; 0007-4142; 65841-619; 58118-0163; 0781-5223; 0378-3632; 68071-5275; 55154-5675; 66022-0120; 0007-4139; 55154-5677; 68788-7458; 71335-1937; 0378-3631; 0093-0135; 43063-129; 70934-516; 0615-7945; 62756-122; 55111-253; 71335-1463; 72888-035; 65841-616; 68788-9265; 70934-653; 68071-3269; 72888-036
Synonyms Carvedilol | Carvedilol Hydrochloride | Dilatrend | Querto | Eucardic | Carvedilol, (S)-isomer | Kredex | BM 14190 | BM-14190 | BM14190 | Carvedilol, (R)-isomer | Carvedilol, (+)-isomer | Carvedilol, (+) | Carvedilol, (+-)-isomer | Carvedilol, (-)-isomer | Carvedilol, (-) | Carvedilol, 14C-labeled | 14C-labeled Carvedilol | Carvedilol, 14C labeled | Coropres | Coreg
Chemical Information
Molecular Formula C24H26N2O4
CAS Registry Number 72956-09-3
SMILES COC1=CC=CC=C1OCCNCC(COC2=CC=CC3=C2C4=CC=CC=C4N3)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Adverse drug reactionCytochrome P450 2D6P10635T5739210772431; 15748098; 10983742
Adverse drug reactionCytochrome P450 2D6P10635T57392Not Available
Atrioventricular block first degreeCytochrome P450 2D6P10635T5739210772431; 15748098; 10983742
Atrioventricular block first degreeCytochrome P450 2D6P10635T57392Not Available
Heart rate decreasedCytochrome P450 2D6P10635T5739210772431; 15748098; 10983742
Heart rate decreasedCytochrome P450 2D6P10635T57392Not Available
Left ventricular dysfunctionATP-dependent translocase ABCB1P08183T2525816800371; 12453548; 11738299
Vascular disordersProto-oncogene tyrosine-protein kinase SrcP12931T8594326327764
Vascular disordersVascular endothelial growth factor receptor 2P35968T8097526327764
Vascular disordersMitogen-activated protein kinase 1P28482T5897026327764
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Catatonia19.11.01.0010.000197%Not Available
Cerebral infarction24.04.06.002; 17.08.01.0040.000197%Not Available
Cerebral thrombosis24.01.04.003; 17.08.01.0060.000098%Not Available
Cerebrovascular accident24.03.05.001; 17.08.01.007--
Cerebrovascular disorder24.03.05.002; 17.08.02.002--Not Available
Chest discomfort02.02.02.009; 22.02.08.001; 08.01.08.0190.000590%Not Available
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.0110.000492%Not Available
Chronic obstructive pulmonary disease22.03.01.0070.000026%Not Available
Circulatory collapse24.06.02.0010.000344%Not Available
Coagulopathy01.01.02.001--Not Available
Cold sweat23.02.03.002; 08.01.03.0240.000492%Not Available
Coma17.02.09.0010.000148%Not Available
Completed suicide19.12.01.001; 08.04.01.0100.000423%Not Available
Confusional state17.02.03.005; 19.13.01.001--
Constipation07.02.02.001--
Cough22.02.03.001--
Death08.04.01.001--
Dehydration14.05.05.0010.000492%
Delirium19.13.02.0010.000098%
Depressed level of consciousness17.02.04.0020.000148%
Depressed mood19.15.02.001--Not Available
Depression19.15.01.001--
Dermatitis23.03.04.002--Not Available
Dermatitis exfoliative10.01.01.004; 23.03.07.001--
Diabetes mellitus14.06.01.001; 05.06.01.0010.000197%Not Available
Diarrhoea07.02.01.001--
Discomfort08.01.08.003--Not Available
Disorientation19.13.01.002; 17.02.05.0150.000098%Not Available
Disturbance in attention19.21.02.002; 17.03.03.001--
Dizziness02.01.02.004; 24.06.02.007; 17.02.05.0030.002262%
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