Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Carmustine
Drug ID BADD_D00371
Description A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (From Merck Index, 11th ed)
Indications and Usage For the treatment of brain tumors, multiple myeloma, Hodgkin's disease and Non-Hodgkin's lymphomas.
Marketing Status Prescription
ATC Code L01AD01
DrugBank ID DB00262
KEGG ID D00254
MeSH ID D002330
PubChem ID 2578
TTD Drug ID D01OXI
NDC Product Code 70121-1482; 50683-0017; 76339-121; 0781-3474; 59651-168; 24338-050; 68475-503; 54893-0055; 23155-649; 57821-002; 55718-139; 23155-790; 43598-628; 59981-034; 70710-1525; 58621-002; 57884-0032; 54879-036; 23155-261; 71288-126
Synonyms Carmustine | BCNU | N,N'-Bis(2-Chloroethyl)-N-Nitrosourea | FIVB | 1,3-Bis(2-Chloroethyl)-1-Nitrosourea | BiCNU | Nitrumon
Chemical Information
Molecular Formula C5H9Cl2N3O2
CAS Registry Number 154-93-8
SMILES C(CCl)NC(=O)N(CCCl)N=O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
GliomaMethylated-DNA--protein-cysteine methyltransferaseP16455T2458711070098; 15297393; 12744471
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Urinary incontinence20.02.02.010; 17.05.01.008--
Urinary tract infection20.08.02.001; 11.01.14.004--
Vasospasm24.04.02.002--Not Available
Vision blurred17.17.01.010; 06.02.06.007--
Visual field defect17.17.01.001; 06.02.07.003--Not Available
Visual impairment06.02.06.008--Not Available
Vomiting07.01.07.003--
Wound dehiscence12.02.05.003--
Wound infection12.01.08.012; 11.01.08.0100.001332%
Brain oedema12.01.10.010; 17.07.02.0030.004795%
Tumour haemorrhage24.07.01.028; 16.32.03.0080.000799%
Deep vein thrombosis24.01.02.0030.000799%Not Available
Malignant neoplasm progression16.16.01.0050.000278%Not Available
Wound12.01.08.009--Not Available
Musculoskeletal discomfort15.03.04.001--Not Available
Cerebral haematoma24.07.04.006; 17.08.01.0140.000208%Not Available
Transaminases increased13.03.01.015--Not Available
Haemorrhage24.07.01.0020.000533%Not Available
Staphylococcal infection11.02.05.0020.000533%Not Available
Dysplasia08.03.04.007--Not Available
Gastrointestinal toxicity12.03.01.019; 07.08.03.006--Not Available
Cerebral vasoconstriction24.04.06.025; 17.08.02.0120.000533%Not Available
Blood alkaline phosphatase increased13.04.02.004--
Bacterial infection11.02.01.0050.000533%Not Available
Brain neoplasm17.20.01.003; 16.30.01.003--Not Available
Connective tissue disorder15.06.01.006--Not Available
Ocular toxicity12.03.01.031; 06.11.01.006--Not Available
Malnutrition14.03.02.004--Not Available
Mental disorder19.07.01.002--Not Available
Decreased appetite14.03.01.005; 08.01.09.0280.001066%
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