Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Carboplatin
Drug ID BADD_D00364
Description Carboplatin is an organoplatinum antineoplastic alkylating agent used in the treatment of advanced ovarian carcinoma.[L32253] Early clinical studies of carboplatin were performed in 1982.[A230523] Carboplatin was developed as an analog of [cisplatin] with reduced nephrotoxicity and vomiting.[A230463,A230523] Carboplatin was granted FDA approval on 3 March 1989.[L32248]
Indications and Usage Carboplatin is indicated in combination with an established combination of chemotherapeutic agents for the initial treatment of advanced ovarian carcinoma.[L32253] Carboplatin is also indicated for the palliative treatment of ovarian carcinoma, recurrent after prior chemotherapy.[L32253]
Marketing Status approved
ATC Code L01XA02
DrugBank ID DB00958
KEGG ID D01363
MeSH ID D016190
PubChem ID 426756
TTD Drug ID D0X7HM
NDC Product Code 0703-4239; 55150-386; 63323-172; 68083-191; 63592-0271; 61703-339; 0703-4244; 0703-4246; 72659-863; 50742-447; 69448-005; 61703-600; 55150-334; 61703-262; 61703-360; 71288-100; 49812-0010; 16729-295; 55150-333; 61703-150; 68083-193; 68554-0084; 68083-190; 68083-192; 53104-7570; 54875-0002; 50742-448; 55150-335; 0703-4248
UNII BG3F62OND5
Synonyms Carboplatin | cis-Diammine(cyclobutanedicarboxylato)platinum II | CBDCA | Paraplatin | Paraplatine | Platinwas | Ribocarbo | Carboplat | Neocarbo | Carbosin | Carbotec | Ercar | JM-8 | JM 8 | JM8 | Nealorin | NSC-241240 | NSC 241240 | NSC241240 | Blastocarb
Chemical Information
Molecular Formula C6H12N2O4Pt
CAS Registry Number 41575-94-4
SMILES C1CC(C1)(C(=O)O)C(=O)O.[NH2-].[NH2-].[Pt+2]
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Brain neoplasm17.20.01.003; 16.30.01.0030.000112%Not Available
Cardiac disorder02.11.01.003--Not Available
Connective tissue disorder10.04.04.026; 15.06.01.006--Not Available
Embolism24.01.01.0090.000392%
Haematotoxicity12.03.01.025; 01.05.01.0070.001903%Not Available
Malnutrition14.03.02.0040.000358%Not Available
Mediastinal disorder22.09.03.0010.000168%Not Available
Metastatic neoplasm16.16.01.0070.000526%Not Available
Neoplasm progression16.16.02.0050.003503%Not Available
Decreased appetite14.03.01.005; 08.01.09.0280.004242%
Renal function test abnormal13.13.01.012--Not Available
Renal injury20.01.03.015; 12.01.05.0010.000112%Not Available
Ill-defined disorder08.01.03.049--Not Available
Disease progression08.01.03.0380.005899%
Disease recurrence08.01.03.0500.001399%Not Available
Fat necrosis08.03.03.0040.000112%Not Available
Neoplasm recurrence16.16.02.0040.000336%Not Available
Obstructive airways disorder22.03.01.0110.000112%Not Available
Pulmonary toxicity22.01.02.007; 12.03.01.0130.000280%Not Available
Lung neoplasm22.08.01.006; 16.19.04.0010.000112%Not Available
Large intestinal obstruction07.13.03.0030.000168%
Venoocclusive disease24.03.02.0160.000224%Not Available
Metastasis16.22.01.0010.000448%Not Available
Renal impairment20.01.03.0100.001477%Not Available
Neuromuscular toxicity17.05.03.008; 12.03.01.0300.000112%Not Available
Non-cardiac chest pain22.12.02.009; 08.01.08.0060.000112%
Arterial occlusive disease24.04.02.0210.000112%Not Available
Neutropenic colitis07.08.01.014; 01.02.03.0100.000392%Not Available
Anaphylactoid shock24.06.02.005; 10.01.07.0040.000336%Not Available
Hypophagia19.09.01.004; 14.03.01.006; 07.01.06.0100.001724%Not Available
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ADReCS-Target
Drug Name ADR Term Target
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