Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Carbamazepine
Drug ID BADD_D00356
Description Carbamazepine, also known as Tegretol, is an anticonvulsant drug and analgesic drug used to control seizures and to treat pain resulting from trigeminal neuralgia. It was initially approved by the FDA in 1965.[A180301] Aside from the above uses, this drug is also given to control the symptoms of bipolar 1.[L1335] Interestingly, carbamazepine was the first anticonvulsant used to treat individuals with bipolar disorder.[A180319]
Indications and Usage For the treatment of epilepsy and pain associated with true trigeminal neuralgia.
Marketing Status Prescription; Discontinued
ATC Code N03AF01
DrugBank ID DB00564
KEGG ID D00252
MeSH ID D002220
PubChem ID 2554
TTD Drug ID D04MSM
NDC Product Code 60687-594; 51672-4123; 70518-3174; 67296-1637; 0781-5988; 68094-008; 0078-0509; 16571-682; 68084-561; 50090-5740; 68084-562; 0121-1894; 75834-221; 63629-8753; 70518-0181; 0904-7116; 68788-7825; 71335-0461; 51672-4047; 60505-2807; 60429-032; 50090-0384; 68071-4313; 0904-6172; 48087-0051; 70518-1769; 75834-220; 70518-2456; 68382-555; 42419-014; 29033-004; 30698-421; 16571-681; 16714-063; 0781-5987; 38779-0114; 50268-171; 70518-1433; 72189-157; 51927-2176; 54092-172; 13668-268; 51672-4124; 71930-072; 51552-0653; 70518-3176; 54092-173; 0615-3505; 0078-0508; 51672-4149; 35561-355; 65344-0028; 70518-1545; 0093-0090; 16714-065; 68382-557; 43063-328; 68788-7210; 0078-0512; 71930-073; 70518-3335; 68382-556; 71335-1730; 29033-019; 67386-621; 70518-3146; 70518-1436; 0781-8016; 51407-215; 49452-1705; 0832-6023; 43353-953; 70518-3266; 16714-064; 55154-1396; 76003-0251; 0078-0511; 0615-8125; 66993-409; 60505-2805; 60429-934; 51672-4150; 0093-0778; 17856-0407; 72664-218; 66993-407; 70518-2426; 51672-4151; 0832-6024; 63629-8255; 50090-2161; 70771-1469; 62512-0024; 70966-0020; 68094-007; 16571-680; 70518-2489; 60687-479; 70771-1470; 71205-025; 48087-0052; 35561-357; 51672-4005; 0121-1724; 13668-271; 60432-129; 71610-336; 60687-583; 63629-8743; 0121-0947; 70518-2841; 62991-1027; 35561-356; 0093-0109; 30698-419; 0904-6885; 70518-2653; 71930-074; 63552-060; 50090-4443; 63629-8721; 65372-1102; 71335-0691; 66993-408; 54092-171; 70771-1468; 63629-8720; 70518-2242; 0832-6022; 60505-0183; 60505-2806; 58118-0268; 0078-0510; 63629-8715; 51672-4041; 71335-0462; 50268-170; 29033-020; 0121-0862; 70518-0902; 50268-172; 0904-3854; 51672-4125; 30698-423
Synonyms Carbamazepine | Carbamazepine Acetate | Carbamazepine Dihydrate | Carbamazepine Hydrochloride | Carbamazepine L-Tartrate (4:1) | Carbamazepine Anhydrous | Carbamazepine Sulfate (2:1) | Carbazepin | Epitol | Finlepsin | Neurotol | Tegretol | Amizepine | Carbamazepine Phosphate
Chemical Information
Molecular Formula C15H12N2O
CAS Registry Number 298-46-4
SMILES C1=CC=C2C(=C1)C=CC3=CC=CC=C3N2C(=O)N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Drug dependenceBifunctional epoxide hydrolase 2P34913T357348877250; 3146222; 8968658; 10380060
HepatotoxicityCytochrome P450 3A4P08684T378481575766; 8723729; 8347124
HypersensitivityEpoxide hydrolase 1P07099Not Available7503783; 7503784
Nephropathy toxicGlutathione hydrolase 1 proenzymeP19440Not Available8125216; 8457719; 1508841; 7785052; 15856183; 8494733; 8720036; 15223355
PorphyriaDelta-aminolevulinic acid dehydrataseQ5TJH2Not Available3181278; 6428897; 71507; 4067519; 3130256; 913061; 7120315; 463487; 4096716; 2500271; 6780356; 3813879; 2429498; 1165472; 6896622; 6800821
PorphyriaDelta-aminolevulinic acid dehydrataseP13716T205143181278; 6428897; 71507; 4067519; 3130256; 913061; 7120315; 463487; 4096716; 2500271; 6780356; 3813879; 2429498; 1165472; 6896622; 6800821
Renal impairmentBeta-2-microglobulinP61769T580803280573; 2679841; 6392147
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Tachyphrenia17.03.03.007; 19.10.03.0100.001263%Not Available
Excessive eye blinking17.17.02.010; 06.05.01.0040.001263%Not Available
Prominent epicanthal folds06.06.04.022; 03.01.07.0030.000220%Not Available
Mucosal hyperaemia08.01.06.0220.001263%Not Available
Stress cardiomyopathy24.04.04.026; 02.04.01.0120.002947%Not Available
Vasoplegia syndrome24.06.03.011; 12.02.01.0100.001263%Not Available
Oral mucosal erythema07.05.05.0230.000842%Not Available
Delivery18.08.02.0060.000842%Not Available
Skin plaque23.03.03.0440.002526%Not Available
Mitochondrial enzyme deficiency14.14.06.003; 03.08.06.0030.001263%Not Available
Overlap syndrome15.06.01.016; 10.04.04.016; 23.03.02.0180.003368%Not Available
Frontotemporal dementia19.20.02.008; 17.03.01.0070.001263%Not Available
Coma scale abnormal13.07.03.0120.003789%Not Available
Roseolovirus test positive13.08.03.0320.002526%Not Available
Motor developmental delay17.01.02.023; 19.22.01.0050.003368%Not Available
False positive investigation result13.18.01.0070.000842%Not Available
Skeletal dysplasia15.11.01.007; 03.11.01.0070.000842%Not Available
Fulminant type 1 diabetes mellitus05.06.01.013; 14.06.01.0130.001263%Not Available
Decerebrate posture15.03.01.024; 17.02.05.0540.000842%Not Available
Craniofacial deformity15.11.02.005; 03.11.02.0050.000220%Not Available
Hypoosmolar state14.05.01.0100.000842%Not Available
Haemorrhagic necrotic pancreatitis24.07.02.047; 07.18.01.0100.000842%Not Available
Infantile apnoea22.11.02.004; 18.04.15.0030.000842%Not Available
Neuromyelitis optica spectrum disorder06.04.08.003; 17.16.02.005; 10.04.10.0150.000842%Not Available
Selective eating disorder19.09.01.012; 14.03.02.0240.000842%Not Available
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